KCNIP2 - potassium voltage-gated channel interacting protein 2 Gene

Also Known as KCHIP2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 30819

About KCNIP2

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:101,825,974-101,843,800 (from NCBI)

This gene has 14 transcripts (splice variants), 268 orthologues and 14 paralogues. Biased expression in fat (RPKM 117.8), heart (RPKM 37.5) and 1 other tissue.

Summary

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each Other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008]

KCNIP2 Products (7)

mRNA	Protein	Name
NM_014591.5	NP_055406.2	Kv channel-interacting protein 2 isoform 1
NM_173191.3	NP_775283.1	Kv channel-interacting protein 2 isoform 2
NM_173192.3	NP_775284.1	Kv channel-interacting protein 2 isoform 3
NM_173193.3	NP_775285.1	Kv channel-interacting protein 2 isoform 4
NM_173194.3	NP_775286.1	Kv channel-interacting protein 2 isoform 5
NM_173195.3	NP_775287.1	Kv channel-interacting protein 2 isoform 6
NM_173197.3	NP_775289.1	Kv channel-interacting protein 2 isoform 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to A-type (transient outward) potassium channel activity	IDA IDA: Inferred from direct assay	21349352	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	15358149	GOA
enables potassium channel regulator activity	IDA IDA: Inferred from direct assay	21493962	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10551270	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	21493962	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in action potential	IDA IDA: Inferred from direct assay	14980201	GOA
involved in clustering of voltage-gated potassium channels	IDA IDA: Inferred from direct assay	11287421	GOA
involved in membrane repolarization	IDA IDA: Inferred from direct assay	14980201	GOA
involved in muscle contraction	IDA IDA: Inferred from direct assay	11287421	GOA
involved in positive regulation of potassium ion export across plasma membrane	IDA IDA: Inferred from direct assay	21349352	GOA
involved in regulation of membrane repolarization	IDA IDA: Inferred from direct assay	21493962	GOA
involved in regulation of potassium ion export across plasma membrane	IDA IDA: Inferred from direct assay	21493962	GOA
involved in regulation of potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	21493962	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Kv4.2-KChIP2 channel complex	IPI IPI: Inferred from physical interaction	14980201	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11287421	GOA
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	21493962	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNIP2 Protein Structure

EF-hand_8

EF-hand_7

0
100
200
270 a.a.

Protein Preferred Names	Protein Names
Kv channel-interacting protein 2	A-type potassium channel modulatory protein 2

KCNIP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KCNIP2	Q9NS61	KCND2	Homo sapiens	Q9NZV8	EM	14980201

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia Type 19/22	Sca19/22 Spinocerebellar Ataxia 19 And 22
Brugada Syndrome	Sudden Unexpected Nocturnal Death Syndrome Sudden Unexplained Nocturnal Death Syndrome Bangungut Brugada Type Idiopathic Ventricular Fibrillation Pokkuri Death Syndrome Sunds Idiopathic Ventricular Fibrillation, Brugada Type Sudden Unexplained Death Dream Disease Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome Sudden Unexplained Death Syndrome Suds Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Cardiomyopathy, Dilated, 1e	Left Ventricular Noncompaction 9 Left Ventricular Noncompaction 5 Dilated Cardiomyopathy 1e Dilated Cardiomyopathy 1s CMD1E Cdcd2 Cardiomyopathy, Dilated, 1y CMD1Y Cardiomyopathy, Dilated, 1s CMD1S Dilated Cardiomyopathy 1y Dilated Cardiomyopathy With Conduction Defect 2 Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia Cardiomyopathy, Dilated, With Conduction Defect 2 Cardiomyopathy Dilated With Conduction Defect Type 2 Cardiomyopathy, Dilated 1e Cardiomyopathy, Dilated 1s Cardiomyopathy, Dilated 1y Left Ventricular Non-Compaction 5 LVNC5 Left Ventricular Non-Compaction 9 LVNC9 Cardiomyopathy, Dilated, Type 1e Cardiomyopathy, Dilated, Type 1s Cardiomyopathy, Dilated, Type 1y
Spinocerebellar Ataxia 13	Spinocerebellar Ataxia Type 13 SCA13 Autosomal Dominant Cerebellar Ataxia With Intellectual Disability Cerebellar Ataxia, Autosomal Dominant With Intellectual Disability Spinocerebellar Ataxia-13 Ataxia, Spinocerebellar, Type 13
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Long Qt Syndrome 1	Romano-Ward Syndrome LQT1 Ward-Romano Syndrome Rws Ventricular Fibrillation With Prolonged Qt Interval Wrs Long Qt Syndrome 1, Acquired, Susceptibility To Long Qt Syndrome 1, Acquired Romano-Ward Long Qt Syndrome Long Qt Syndrome Type 1 Long Qt Syndrome-1 Acquired Susceptibility To Long Qt Syndrome 1 Qt Syndrome, Long, Type 1
Long Qt Syndrome 2	LQT2 Long Qt Syndrome, Acquired, Reduced Susceptibility To Long Qt Syndrome 1/2 Long Qt Syndrome 2/3 Long Qt Syndrome 2/5 Long Qt Syndrome 2, Acquired, Susceptibility To Long Qt Syndrome, Acquired, Reduced Long Qt Syndrome Type 2 Long Qt Syndrome 2/9 Lqt1/2 Lqt2/3 Lqt2/5 Lqt2/9 Susceptibility To Acquired Long Qt Syndrome 2 Long Qt Syndrome-2 Qt Syndrome, Long, Type 2 Long Qt Syndrome 1-2 Long Qt Syndrome 2-3 Long Qt Syndrome 2-5 Long Qt Syndrome 9
Heart Conduction Disease	Conduction Disorder Of The Heart Heart Rhythm Disease
Long Qt Syndrome	Romano-Ward Syndrome Long Q-T Syndrome Lqt Qt Syndrome, Long Congenital Long Qt Syndrome Familial Long Qt Syndrome
Familial Atrial Fibrillation	Atrial Fibrillation, Familial Atfb Atrial Fibrillation Autosomal Dominant Autosomal Dominant Atrial Fibrillation Auricular Fibrillation Atrial Fibrillation Atrial Fibrillation, Familial, 1
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07133	KCNIP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KCNIP2	VGNC	VGNC:42255
Bos taurus	KCNIP2	VGNC	VGNC:30451
Macaca mulatta	KCNIP2	VGNC	VGNC:73833
Rattus norvegicus	KCNIP2	RGD	RGD:70887
Felis catus	KCNIP2	VGNC	VGNC:63041
Mus musculus	KCNIP2	MGD	MGI:2135916
Others	KCNIP2	NCBI