LMAN2L - lectin, mannose binding 2 like Gene

Homo sapiens

Also known as VIPL; MRD69; MRT52

Gene ID: 81562 | Gene type: protein coding

About LMAN2L

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:96,705,929-96,740,064 (from NCBI)

This gene has 9 transcripts (splice variants), 284 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 11.7), thyroid (RPKM 11.6) and 25 other tissues.

Summary

This gene encodes a protein belonging to the L-type lectin group of type 1 membrane proteins, which function in the mammalian early secretory pathway. These proteins contain luminal carbohydrate recognition domains, which display homology to leguminous lectins. Unlike other proteins of the group, which cycle in the early secretory pathway and are predominantly associated with post endoplasmic reticulum membranes, the protein encoded by this gene is a non-cycling resident protein of the ER, where it functions as a cargo receptor for glycoproteins. It is proposed to regulate exchange of folded proteins for transport to the Golgi and exchange of misfolded glycoproteins for transport to the ubiquitin-proteasome pathway. [provided by RefSeq, Apr 2016]

LMAN2L Products(10)

mRNA	Protein	Name
NM_001142292.2	NP_001135764.1	VIP36-like protein isoform 1 precursor
NM_001322346.2	NP_001309275.1	VIP36-like protein isoform 3
NM_001322347.2	NP_001309276.1	VIP36-like protein isoform 4
NM_001322350.2	NP_001309279.1	VIP36-like protein isoform 5
NM_001322351.2	NP_001309280.1	VIP36-like protein isoform 6
NM_001322352.2	NP_001309281.1	VIP36-like protein isoform 4
NM_001322354.2	NP_001309283.1	VIP36-like protein isoform 3
NM_001322355.2	NP_001309284.1	VIP36-like protein isoform 6
NM_001322356.2	NP_001309285.1	VIP36-like protein isoform 6
NM_030805.4	NP_110432.1	VIP36-like protein isoform 2 precursor

LMAN2L Protein Structure

Lectin_leg-like

0
100
200
300
348 a.a.

Protein Preferred Names

Protein Names

VIP36-like protein

LMAN2-like protein

Recombinant LMAN2L Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70914	LMAN2L Protein, Human (295a.a, HEK293, His)	Q9H0V9 (S19-A313)	≥95%
HY-P76473	LMAN2L Protein, Human (304a.a, HEK293, His)	Q9H0V9 (M1-A304)	≥95%

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Recessive 52

MRT52	Mental Retardation, Autosomal Recessive 52
Autosomal Recessive Intellectual Developmental Disorder 52	Mental Retardation, Autosomal Recessive, 52

Intellectual Developmental Disorder, Autosomal Dominant 69

MRD69

Mental Retardation, Autosomal Dominant 69

Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07705	LMAN2L Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	LMAN2L	VGNC	VGNC:30921
Mus musculus	LMAN2L	MGD	MGI:2443010
Felis catus	LMAN2L	VGNC	VGNC:63247
Canis familiaris	LMAN2L	VGNC	VGNC:42709
Macaca mulatta	LMAN2L	VGNC	VGNC:82175
Rattus norvegicus	LMAN2L	RGD	RGD:1311393
Others	LMAN2L	NCBI

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