2. Gene
  3. Psen2 - presenilin 2 Gene

Psen2 - presenilin 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 81751 | Gene type: protein coding

About Psen2

Summary

Predicted to enable aspartic endopeptidase activity, intramembrane cleaving. Involved in response to hypoxia. Located in early endosome; synaptic membrane; and synaptic vesicle. Is integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; Alzheimer's disease 4; breast cancer; and dilated cardiomyopathy 1V. Orthologous to human PSEN2 (presenilin 2). [provided by Alliance of Genome Resources, Apr 2022]

Psen2 Products(1)

mRNA Protein Name
NM_031087.2 NP_112349.2 presenilin-2
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
12468103 RGD
Cellular Component GO Annotation Evidence Reference Source
located in early endosome IDA
IDA: Inferred from direct assay
20126630 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
20126630 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
20126630 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
20126630 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

presenilin-2

PS-2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11277 PSEN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Psen2 NCBI NCBI:5664