Doc2b - double C2 domain beta Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81820

Summary

Enables calcium-dependent phospholipid binding activity. Involved in calcium ion-regulated exocytosis of neurotransmitter; positive regulation of calcium ion-dependent exocytosis; and positive regulation of vesicle fusion. Located in plasma membrane. Orthologous to human DOC2B (double C2 domain beta). [provided by Alliance of Genome Resources, Apr 2022]

Doc2b Products (1)

mRNA Protein Name
NM_031142.1 NP_112404.1 double C2-like domain-containing protein beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent phospholipid binding IDA
IDA: Inferred from direct assay
18596155 RGD
Biological Process GO Annotation Evidence References Source
involved in calcium ion-regulated exocytosis of neurotransmitter IDA
IDA: Inferred from direct assay
20150444 RGD
involved in calcium-dependent activation of synaptic vesicle fusion IDA
IDA: Inferred from direct assay
22036572 RGD
involved in calcium-dependent activation of synaptic vesicle fusion IMP
IMP: Inferred from mutant phenotype
22036572 RGD
involved in exocytosis IEP
IEP: Inferred from expression pattern
10651871 RGD
involved in positive regulation of calcium ion-dependent exocytosis IDA
IDA: Inferred from direct assay
18596155 RGD
involved in positive regulation of vesicle fusion IDA
IDA: Inferred from direct assay
18596155 RGD
Cellular Component GO Annotation Evidence References Source
part of SNARE complex IDA
IDA: Inferred from direct assay
18596155 RGD
is active in extrinsic component of synaptic vesicle membrane IDA
IDA: Inferred from direct assay
9115738 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
22036572 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
22036572 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
18596155 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

double C2-like domain-containing protein beta

  • doc2-beta

  • double C2, beta

  • double C2-like domains, beta

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03920 DOC2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Doc2b NCBI NCBI:8447