Rab11a - RAB11a, member RAS oncogene family Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 81830

Summary

Enables GTP binding activity and GTPase activity. Involved in several processes, including neurotransmitter receptor transport, endosome to postsynaptic membrane; positive regulation of protein localization to plasma membrane; and regulation of long-term neuronal synaptic plasticity. Located in postsynaptic recycling endosome and transport vesicle. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Orthologous to human RAB11A (RAB11A, member Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Rab11a Products (1)

mRNA	Protein	Name
NM_031152.3	NP_112414.1	ras-related protein Rab-11A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTP binding	IDA IDA: Inferred from direct assay	17158030	RGD
enables GTPase activity	IDA IDA: Inferred from direct assay	16473307	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in neurotransmitter receptor transport, endosome to postsynaptic membrane	IDA IDA: Inferred from direct assay	18045925	RGD
involved in neurotransmitter receptor transport, endosome to postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	18045925	RGD
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	19542231	RGD
involved in regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	18045925	RGD
involved in regulation of protein transport	IMP IMP: Inferred from mutant phenotype	18045925	RGD
involved in synaptic vesicle endosomal processing	EXP EXP: Inferred from Experiment	30301801	RGD
involved in synaptic vesicle endosomal processing	IDA IDA: Inferred from direct assay	30301801	RGD
involved in synaptic vesicle endosomal processing	IMP IMP: Inferred from mutant phenotype	30301801	RGD
involved in vesicle-mediated transport in synapse	IDA IDA: Inferred from direct assay	18045925	RGD
involved in vesicle-mediated transport in synapse	IMP IMP: Inferred from mutant phenotype	18045925	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	18045925	RGD
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	18045925	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	18045925	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	18045925	RGD
is active in presynaptic endosome	EXP EXP: Inferred from Experiment	30301801	RGD
is active in presynaptic endosome	IDA IDA: Inferred from direct assay	30301801	RGD
is active in presynaptic endosome	IMP IMP: Inferred from mutant phenotype	30301801	RGD
located in recycling endosome	IDA IDA: Inferred from direct assay	10468577	RGD
is active in synaptic vesicle membrane	EXP EXP: Inferred from Experiment	33376223	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	33376223	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ras-related protein Rab-11A	24KG rab-11

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11515	RAB11A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rab11a	NCBI	NCBI:8766