Tmem108 - transmembrane protein 108 Gene

Also Known as B130017P16Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 81907

Summary

Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; nervous system development; and regulation of signal transduction. Located in several cellular components, including axon; endosome; and postsynaptic density. Is expressed in 4th ventricle lateral recess; cerebral cortex marginal layer; and lateral ventricle choroid plexus. Orthologous to human TMEM108 (transmembrane protein 108). [provided by Alliance of Genome Resources, Apr 2022]

Tmem108 Products (2)

mRNA	Protein	Name
NM_001359465.1	NP_001346394.1	transmembrane protein 108 precursor
NM_178638.4	NP_848753.1	transmembrane protein 108 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17287360	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to brain-derived neurotrophic factor stimulus	IMP IMP: Inferred from mutant phenotype	21849472	MGI
involved in dendrite extension	IMP IMP: Inferred from mutant phenotype	21849472	MGI
involved in dentate gyrus development	IMP IMP: Inferred from mutant phenotype	28096412	MGI
involved in modulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	28096412	MGI
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	21849472	MGI
involved in positive regulation of neurotrophin TRK receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21849472	MGI
involved in postsynaptic density organization	IMP IMP: Inferred from mutant phenotype	28096412	MGI
involved in receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	27605705	MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	28096412	MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	28096412	MGI
involved in retrograde axonal transport	IDA IDA: Inferred from direct assay	17287360	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	17287360	MGI
located in early endosome	IDA IDA: Inferred from direct assay	21849472	MGI
located in endosome membrane	IDA IDA: Inferred from direct assay	17287360	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	28096412	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	28096412	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	28096412	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	28096412	MGI
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	28096412	MGI
is active in postsynaptic density membrane	IEP IEP: Inferred from expression pattern	28096412	MGI
is active in postsynaptic density membrane	IMP IMP: Inferred from mutant phenotype	28096412	MGI
located in somatodendritic compartment	IDA IDA: Inferred from direct assay	21849472	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transmembrane protein 108	retrolinkin

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14649	TMEM108 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tmem108	NCBI	NCBI:66000