Pard3 - par-3 family cell polarity regulator Gene

Also Known as Par3

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 81918

Summary

Enables identical protein binding activity; phosphatidylinositol phosphate binding activity; and protein Phosphatase binding activity. Involved in several processes, including bicellular tight junction assembly; establishment of epithelial cell polarity; and protein targeting to membrane. Located in axonal growth cone; cell-cell junction; and neuronal cell body. Part of protein-containing complex. Orthologous to human PARD3 (par-3 family cell polarity regulator). [provided by Alliance of Genome Resources, Apr 2022]

Pard3 Products (1)

mRNA	Protein	Name
NM_031235.2	NP_112514.1	partitioning defective 3 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	23643951	RGD
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA IDA: Inferred from direct assay	18082612	RGD
enables phosphatidylinositol-3-phosphate binding	IDA IDA: Inferred from direct assay	18082612	RGD
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	18082612	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16474385	RGD
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	18082612	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	18082612	RGD
involved in establishment of epithelial cell polarity	IMP IMP: Inferred from mutant phenotype	18082612	RGD
involved in protein targeting to membrane	IDA IDA: Inferred from direct assay	18550519	RGD
involved in regulation of cellular localization	IMP IMP: Inferred from mutant phenotype	18621709	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axonal growth cone	IDA IDA: Inferred from direct assay	15090620	RGD
located in cell-cell junction	IDA IDA: Inferred from direct assay	18082612	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15090620	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	18621709	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
partitioning defective 3 homolog	ASBP ASIP PARD-3 atypical PKC isotype-specific-interacting protein atypical PKC-specific binding protein par-3 (partitioning defective 3) homolog three-PDZ containing protein similar to C. elegans PAR3 (partitioning defect)

Pard3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Pard3	Q9Z340	F11r	Rattus norvegicus	Q9JHY1	Pull Down	11447115
Intra	Pard3	Q9Z340	Pard3	Rattus norvegicus	Q9Z340	AFM	23643951
Intra	Pard3	Q9Z340	Pard3	Rattus norvegicus	Q9Z340	Crosslink	23643951
Intra	Pard3	Q9Z340	Pard3	Rattus norvegicus	Q9Z340	TEM	23643951
Intra	Pard3	Q9Z340	Pard3	Rattus norvegicus	Q9Z340	X-Ray Diffraction	23643951
Intra	Pard3	Q9Z340	Pard3	Rattus norvegicus	Q9Z340	GMS	23643951
Intra	Pard3	Q9Z340	Pard3	Rattus norvegicus	Q9Z340	3D-EM	23643951

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10037	PARD3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pard3	NCBI	NCBI:56288