Sacm1l - SAC1 suppressor of actin mutations 1-like (yeast) Gene

Mus musculus

Also known as SAC1; Sac1p; mKIAA0851

Gene ID: 83493 | Gene type: protein coding

About Sacm1l

Summary

This gene encodes an integral membrane protein, which is localized to the endoplasmic reticulum, and functions as a phosphoinositide Phosphatase that hydrolyzes phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol 3,5-bisphosphate. Deletion of this gene in mouse results in preimplantation lethality. Other studies suggest that this gene is also involved in the organization of golgi membranes and mitotic spindles. Two isoforms are predicted to be produced from the same mRNA by the use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Dec 2017]

Sacm1l Products(2)

mRNA	Protein	Name
NM_001357485.1	NP_001344414.1	phosphatidylinositol-3-phosphatase SAC1 isoform 1x
NM_030692.5	NP_109617.1	phosphatidylinositol-3-phosphatase SAC1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	34237247	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane	IDA IDA: Inferred from direct assay	32931550	MGI
involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane	IMP IMP: Inferred from mutant phenotype	32931550	MGI
involved in vesicle-mediated transport in synapse	IDA IDA: Inferred from direct assay	32931550	MGI
involved in vesicle-mediated transport in synapse	IMP IMP: Inferred from mutant phenotype	32931550	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of AMPA glutamate receptor complex	IDA IDA: Inferred from direct assay	22632720	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	32931550	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	32931550	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phosphatidylinositol-3-phosphatase SAC1

phosphatidylinositide phosphatase SAC1	phosphatidylinositol-4-phosphate phosphatase
polyphosphatidylinositol phosphatase	suppressor of actin mutations 1-like protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12410	SACM1L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sacm1l	NCBI	NCBI:22908

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