Sacm1l - SAC1 suppressor of actin mutations 1-like (yeast) Gene

Also Known as SAC1; Sac1p; mKIAA0851

Species: Mus musculus

Gene Type: protein coding
Gene ID: 83493

Summary

This gene encodes an integral membrane protein, which is localized to the endoplasmic reticulum, and functions as a phosphoinositide Phosphatase that hydrolyzes phosphatidylinositol 3-phosphate, phosphatidylinositol 4-phosphate, and phosphatidylinositol 3,5-bisphosphate. Deletion of this gene in mouse results in preimplantation lethality. Other studies suggest that this gene is also involved in the organization of golgi membranes and mitotic spindles. Two isoforms are predicted to be produced from the same mRNA by the use of alternative in-frame translation termination codons via a stop codon readthrough mechanism. [provided by RefSeq, Dec 2017]

Sacm1l Products (2)

mRNA Protein Name
NM_001357485.1 NP_001344414.1 phosphatidylinositol-3-phosphatase SAC1 isoform 1x
NM_030692.5 NP_109617.1 phosphatidylinositol-3-phosphatase SAC1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
34237247 MGI
Biological Process GO Annotation Evidence References Source
involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IDA
IDA: Inferred from direct assay
32931550 MGI
involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane IMP
IMP: Inferred from mutant phenotype
32931550 MGI
involved in vesicle-mediated transport in synapse IDA
IDA: Inferred from direct assay
32931550 MGI
involved in vesicle-mediated transport in synapse IMP
IMP: Inferred from mutant phenotype
32931550 MGI
Cellular Component GO Annotation Evidence References Source
part of AMPA glutamate receptor complex IDA
IDA: Inferred from direct assay
22632720 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
32931550 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
32931550 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphatidylinositol-3-phosphatase SAC1

  • phosphatidylinositide phosphatase SAC1

  • phosphatidylinositol-4-phosphate phosphatase

  • polyphosphatidylinositol phosphatase

  • suppressor of actin mutations 1-like protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12410 SACM1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sacm1l NCBI NCBI:22908