AIFM1 - Aifm1 apoptosis inducing factor, mitochondria associated 1 Gene

Also Known as Aif; Pdcd8

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83533

Summary

Predicted to enable DNA binding activity; FAD binding activity; and NAD(P)H oxidase H2O2-forming activity. Involved in several processes, including cellular response to lipid; cellular response to nitric oxide; and cellular response to oxygen-glucose deprivation. Located in cytosol; mitochondrion; and nucleus. Biomarker of middle cerebral artery infarction; retinal detachment; retinitis pigmentosa; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked recessive 4; X-linked deafness 5; and combined Oxidative Phosphorylation deficiency 6. Orthologous to several human genes including TXNDC12 (thioredoxin domain containing 12). [provided by Alliance of Genome Resources, Apr 2022]

AIFM1 Products (1)

mRNA Protein Name
NM_031356.2 NP_112646.1 apoptosis-inducing factor 1, mitochondrial precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cellular response to aldosterone IEP
IEP: Inferred from expression pattern
24551180 RGD
involved in cellular response to estradiol stimulus IEP
IEP: Inferred from expression pattern
16776830 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
11781347 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
14526224 RGD
involved in cellular response to nitric oxide IEP
IEP: Inferred from expression pattern
18560609 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
20177052 RGD
involved in response to L-glutamate IEP
IEP: Inferred from expression pattern
16776830 RGD
NOT involved in response to ischemia IEP
IEP: Inferred from expression pattern
23685150 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
15181376 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
11781347 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

apoptosis-inducing factor 1, mitochondrial

  • apoptosis-inducing factor 1, mitochondrial-like

  • apoptosis-inducing factor, mitochondrion-associated 1

  • programmed cell death 8 (apoptosis-inducing factor)

  • programmed cell death protein 8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-180948 PZ-11 Inducer / Unkown
HY-RS00492 AIFM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19406 Aifm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25898 Aifm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens AIFM1 NCBI NCBI:9131