H4C11 - H4 clustered histone 11 Gene

Also Known as H4/e; H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4FE; H4-16; H4C12; H4C13; H4C14; H4C15; H4C16; H4F2iv; HIST1H4J; TEVANED2; TEBIVANED2; dJ160A22.2

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 8363

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

H4C11 Products (1)

mRNA Protein Name
NM_021968.4 NP_068803.1 histone H4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9540062 GOA
enables structural constituent of chromatin IDA
IDA: Inferred from direct assay
14718166 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of megakaryocyte differentiation IDA
IDA: Inferred from direct assay
18474616 GOA
involved in nucleosome assembly IDA
IDA: Inferred from direct assay
14718166 GOA
Cellular Component GO Annotation Evidence References Source
part of CENP-A containing nucleosome IPI
IPI: Inferred from physical interaction
21743476 GOA
part of nucleosome IDA
IDA: Inferred from direct assay
14718166 GOA
part of nucleosome IPI
IPI: Inferred from physical interaction
20498094 GOA
located in nucleus IDA
IDA: Inferred from direct assay
14585971 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
14718166 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone H4

  • H4 histone family, member E

  • histone 1, H4j

  • histone cluster 1 H4 family member j

  • histone cluster 1, H4j

Recombinant H4C11 Proteins

Cat. No. Product Name Accession Purity
HY-P72336 Histone H4 Protein, Human/Xenopus laevis P62805 (S2-G103) ≥ 95%, as determined by reducing SDS-PAGE.

H4C11 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86642 Histone H4 Antibody (YA6334) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05974 H4C1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05975 H4C2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05976 H4C3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05977 H4C4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05978 H4C6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05979 H4C8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19607 H4c1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown