Slc26a5 - solute carrier family 26 member 5 Gene

Rattus norvegicus

Also known as Pres; prestin

Gene ID: 83819 | Gene type: protein coding

About Slc26a5

Summary

Enables identical protein binding activity. Involved in several processes, including chloride transmembrane transport; cochlea development; and response to ischemia. Located in basolateral plasma membrane; cytoplasm; and lateral plasma membrane. Biomarker of hypothyroidism. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 61. Orthologous to human SLC26A5 (solute carrier family 26 member 5). [provided by Alliance of Genome Resources, Apr 2022]

Slc26a5 Products(1)

mRNA	Protein	Name
NM_030840.1	NP_110467.1	prestin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chloride:bicarbonate antiporter activity	IDA IDA: Inferred from direct assay	22890707	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	17998209	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in bicarbonate transport	IDA IDA: Inferred from direct assay	22890707	RGD
involved in chloride transmembrane transport	IMP IMP: Inferred from mutant phenotype	11423665	RGD
involved in chloride transport	IDA IDA: Inferred from direct assay	22890707	RGD
involved in cochlea development	IEP IEP: Inferred from expression pattern	20006695	RGD
involved in fructose transmembrane transport	IDA IDA: Inferred from direct assay	12938672	RGD
involved in monoatomic anion transmembrane transport	IDA IDA: Inferred from direct assay	22063625	RGD
involved in monoatomic ion transmembrane transport	IDA IDA: Inferred from direct assay	11274441	RGD
involved in negative regulation of monoatomic ion transmembrane transport	IDA IDA: Inferred from direct assay	15660259	RGD
involved in oxalate transport	IDA IDA: Inferred from direct assay	24710176	RGD
involved in positive regulation of cell motility	IDA IDA: Inferred from direct assay	11274441	RGD
involved in positive regulation of cell size	IDA IDA: Inferred from direct assay	12938672	RGD
involved in response to auditory stimulus	IEP IEP: Inferred from expression pattern	17005342	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	15925203	RGD
involved in response to potassium ion	IEP IEP: Inferred from expression pattern	21624428	RGD
involved in response to salicylic acid	IEP IEP: Inferred from expression pattern	19173110	RGD
involved in response to salt	IEP IEP: Inferred from expression pattern	21624428	RGD
involved in response to thyroid hormone	IEP IEP: Inferred from expression pattern	11867734	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	20006695	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	20525072	RGD
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	11867734	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

prestin

prestin (motor protein)

solute carrier family 26 (anion exchanger), member 5

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13139	SLC26A5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc26a5	NCBI	NCBI:375611

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