Dnaja3 - DnaJ heat shock protein family (Hsp40) member A3 Gene

Also Known as Tid-1; Tid1l; 1200003J13Rik; 1810053A11Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 83945

Summary

Enables GTPase regulator activity; receptor tyrosine kinase binding activity; and unfolded protein binding activity. Involved in skeletal muscle acetylcholine-gated channel clustering. Acts upstream of or within several processes, including activation-induced cell death of T cells; mitochondrial DNA replication; and positive regulation of T cell proliferation. Located in several cellular components, including mitochondrion; neuromuscular junction; and postsynaptic membrane. Is extrinsic component of plasma membrane. Orthologous to human DNAJA3 (DnaJ heat shock protein family (HSP40) member A3). [provided by Alliance of Genome Resources, Apr 2022]

Dnaja3 Products (2)

mRNA	Protein	Name
NM_001135112.1	NP_001128584.1	dnaJ homolog subfamily A member 3, mitochondrial isoform 2
NM_023646.4	NP_076135.3	dnaJ homolog subfamily A member 3, mitochondrial isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase regulator activity	IDA IDA: Inferred from direct assay	11116152	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14993262	MGI
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	19038220	MGI
enables unfolded protein binding	IPI IPI: Inferred from physical interaction	11116152	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	15879105	MGI
acts upstream of or within activation-induced cell death of T cells	IMP IMP: Inferred from mutant phenotype	15879105	MGI
acts upstream of or within apoptotic process	IMP IMP: Inferred from mutant phenotype	16327803	MGI
acts upstream of or within cellular senescence	IDA IDA: Inferred from direct assay	15572682	MGI
acts upstream of or within embryo development	IMP IMP: Inferred from mutant phenotype	14993262	MGI
acts upstream of or within mitochondrial DNA replication	IMP IMP: Inferred from mutant phenotype	16327803	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	16327803	MGI
acts upstream of or within negative regulation of programmed cell death	IMP IMP: Inferred from mutant phenotype	14993262	MGI
involved in neuromuscular junction development	IMP IMP: Inferred from mutant phenotype	19038220	MGI
acts upstream of or within positive regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	15879105	MGI
involved in skeletal muscle acetylcholine-gated channel clustering	IMP IMP: Inferred from mutant phenotype	19038220	MGI
acts upstream of or within small GTPase-mediated signal transduction	IDA IDA: Inferred from direct assay	11116152	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	19038220	MGI
located in cytosol	IDA IDA: Inferred from direct assay	11116152	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	11116152	MGI
located in mitochondrion	IMP IMP: Inferred from mutant phenotype	14993262	MGI
located in neuromuscular junction	IDA IDA: Inferred from direct assay	19038220	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11116152	MGI
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	19038220	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
dnaJ homolog subfamily A member 3, mitochondrial	DnaJ (Hsp40) homolog, subfamily A, member 3 dnaJ protein Tid-1 mTid-1 tumorous imaginal discs protein Tid56 homolog

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03859	DNAJA3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dnaja3	NCBI	NCBI:9093