FBXO30 - F-box protein 30 Gene

Also Known as Fbx30

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84085

About FBXO30

Cytogenetic location: 6q24.3 Genomic coordinates (GRCh38): 6:145,793,502-145,814,795 (from NCBI)

This gene has 1 transcript (splice variant), 204 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 3.5), testis (RPKM 3.3) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it is upregulated in nasopharyngeal carcinoma. [provided by RefSeq, Jul 2008]

FBXO30 Products (2)

mRNA Protein Name
NM_001348092.2 NP_001335021.1 F-box only protein 30
NM_032145.5 NP_115521.3 F-box only protein 30

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO30 Protein Structure

F-box

F-box: F-box domain (612 - 648)

  • 0
  • 200
  • 400
  • 600
  • 745 a.a.
Protein Preferred Names Protein Names

F-box only protein 30

  • F-box domain protein

FBXO30 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FBXO30 Q8TB52 MYO6 Homo sapiens Q9UM54
Anti Tag CoIP
33961781
Intra
FBXO30 Q8TB52 MYO6 Homo sapiens Q9UM54
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nasopharyngeal Carcinoma

  • Malignant Neoplasm Of Nasopharynx

  • Npc

  • Nasopharyngeal Cancer

  • Nasopharyngeal Carcinoma 1

  • Nasopharynx Carcinoma

  • Nasopharyngeal Neoplasms

  • Npca

  • Carcinoma Of Nasopharynx

  • Malignant Nasopharyngeal Tumor

  • Nasopharynx Cancer

  • Squamous Cell Carcinoma Of The Nasopharynx

  • Nasopharyngeal Neoplasm

  • Cancer Of Nasopharynx
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04818 FBXW7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04802 FBXO30 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17548 Fbxw7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta FBXO30 VGNC VGNC:72510
Rattus norvegicus FBXO30 RGD RGD:1359367
Canis familiaris FBXO30 VGNC VGNC:40772
Felis catus FBXO30 VGNC VGNC:62185
Mus musculus FBXO30 MGD MGI:1919115
Bos taurus FBXO30 VGNC VGNC:28903
Others FBXO30 NCBI