Cacng2 - calcium voltage-gated channel auxiliary subunit gamma 2 Gene

Also Known as Ipr328

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84347

Summary

Enables ionotropic glutamate receptor binding activity. Involved in several processes, including eye blink reflex; positive regulation of AMPA Receptor activity; and positive regulation of protein localization to basolateral plasma membrane. Located in several cellular components, including cell surface; cerebellar mossy fiber; and postsynaptic density membrane. Part of AMPA glutamate receptor complex. Biomarker of childhood absence epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 10. Orthologous to human CACNG2 (calcium voltage-gated channel auxiliary subunit gamma 2). [provided by Alliance of Genome Resources, Apr 2022]

Cacng2 Products (1)

mRNA Protein Name
NM_053351.2 NP_445803.2 voltage-dependent calcium channel gamma-2 subunit

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
17194442 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12359873 RGD
Biological Process GO Annotation Evidence References Source
involved in eye blink reflex IEP
IEP: Inferred from expression pattern
21319893 RGD
involved in positive regulation of AMPA receptor activity IDA
IDA: Inferred from direct assay
16093395 RGD
involved in positive regulation of protein localization to basolateral plasma membrane IDA
IDA: Inferred from direct assay
17986442 RGD
involved in protein targeting to membrane IDA
IDA: Inferred from direct assay
17986442 RGD
involved in regulation of AMPA receptor activity IDA
IDA: Inferred from direct assay
17880894 RGD
involved in response to calcium ion IEP
IEP: Inferred from expression pattern
21256931 RGD
Cellular Component GO Annotation Evidence References Source
part of AMPA glutamate receptor complex IDA
IDA: Inferred from direct assay
19265014 RGD
located in cell surface IDA
IDA: Inferred from direct assay
21276808 RGD
located in cerebellar mossy fiber IDA
IDA: Inferred from direct assay
23751177 RGD
located in postsynaptic density membrane IDA
IDA: Inferred from direct assay
21276808 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent calcium channel gamma-2 subunit

  • TARP gamma-2

  • calcium channel, voltage-dependent, gamma subunit 2

  • neuronal voltage-gated calcium channel gamma-2 subunit

  • stargazin

  • transmembrane AMPAR regulatory protein gamma-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01810 CACNG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cacng2 NCBI NCBI:10369