Cacng2 - calcium voltage-gated channel auxiliary subunit gamma 2 Gene

Rattus norvegicus

Also known as Ipr328

Gene ID: 84347 | Gene type: protein coding

About Cacng2

Summary

Enables ionotropic glutamate receptor binding activity. Involved in several processes, including eye blink reflex; positive regulation of AMPA Receptor activity; and positive regulation of protein localization to basolateral plasma membrane. Located in several cellular components, including cell surface; cerebellar mossy fiber; and postsynaptic density membrane. Part of AMPA glutamate receptor complex. Biomarker of childhood absence epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 10. Orthologous to human CACNG2 (calcium voltage-gated channel auxiliary subunit gamma 2). [provided by Alliance of Genome Resources, Apr 2022]

Cacng2 Products(1)

mRNA	Protein	Name
NM_053351.2	NP_445803.2	voltage-dependent calcium channel gamma-2 subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	17194442	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12359873	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in eye blink reflex	IEP IEP: Inferred from expression pattern	21319893	RGD
involved in positive regulation of AMPA receptor activity	IDA IDA: Inferred from direct assay	16093395	RGD
involved in positive regulation of protein localization to basolateral plasma membrane	IDA IDA: Inferred from direct assay	17986442	RGD
involved in protein targeting to membrane	IDA IDA: Inferred from direct assay	17986442	RGD
involved in regulation of AMPA receptor activity	IDA IDA: Inferred from direct assay	17880894	RGD
involved in response to calcium ion	IEP IEP: Inferred from expression pattern	21256931	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of AMPA glutamate receptor complex	IDA IDA: Inferred from direct assay	19265014	RGD
located in cell surface	IDA IDA: Inferred from direct assay	21276808	RGD
located in cerebellar mossy fiber	IDA IDA: Inferred from direct assay	23751177	RGD
located in postsynaptic density membrane	IDA IDA: Inferred from direct assay	21276808	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

voltage-dependent calcium channel gamma-2 subunit

TARP gamma-2	calcium channel, voltage-dependent, gamma subunit 2
neuronal voltage-gated calcium channel gamma-2 subunit	stargazin
transmembrane AMPAR regulatory protein gamma-2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01810	CACNG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cacng2	NCBI	NCBI:10369

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