2. Gene
  3. Sh3kbp1 - SH3 domain-containing kinase-binding protein 1 Gene

Sh3kbp1 - SH3 domain-containing kinase-binding protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Seta; CIN85

Gene ID: 84357 | Gene type: protein coding

About Sh3kbp1

Summary

Enables ubiquitin protein Ligase binding activity. Predicted to be involved in several processes, including actin filament organization; positive regulation of B cell activation; and regulation of cell shape. Predicted to be located in cell-cell junction and endocytic vesicle. Human ortholog(s) of this gene implicated in immunodeficiency 61. Orthologous to human SH3KBP1 (SH3 domain containing kinase binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Sh3kbp1 Products(1)

mRNA Protein Name
NM_053360.3 NP_445812.1 SH3 domain-containing kinase-binding protein 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11152963 RGD
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
17675467 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
20551902 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
20551902 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
20551902 RGD
is active in synapse IDA
IDA: Inferred from direct assay
16751601 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SH3 domain-containing kinase-binding protein 1

SH3 domain-containing adapter protein

SH3-containing, expressed in tumorigenic astrocytes

SH3-domain kinase binding protein 1

regulator of ubiquitous kinase

ruk

Sh3kbp1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
Sh3kbp1 Q925Q9 ITSN1 Homo sapiens Q15811-2
Pull Down
19166927
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12841 SH3KBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sh3kbp1 NCBI NCBI:30011