2. Gene
  3. Dffb - DNA fragmentation factor subunit beta Gene

Dffb - DNA fragmentation factor subunit beta Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Cad

Gene ID: 84359 | Gene type: protein coding

About Dffb

Summary

Enables deoxyribonuclease activity. Involved in apoptotic DNA fragmentation and brain development. Located in nucleus. Biomarker of transient cerebral ischemia. Orthologous to human DFFB (DNA fragmentation factor subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Dffb Products(1)

mRNA Protein Name
NM_053362.2 NP_445814.1 DNA fragmentation factor subunit beta
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables DNA nuclease activity IDA
IDA: Inferred from direct assay
11425895 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15893727 RGD
Biological Process GO Annotation Evidence Reference Source
involved in apoptotic DNA fragmentation IDA
IDA: Inferred from direct assay
11425895 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA fragmentation factor subunit beta

DFF-40

DNA fragmentation factor 40 kDa subunit

DNA fragmentation factor, 40 kD, beta polypeptide (caspase-activated DNase)

DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)

DNA fragmentation factor, beta polypeptide (caspase-

Dffb Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Dffb Q99N34 Nfkb1 Rattus norvegicus Q63369
Anti Bait CoIP
16642037
Intra
Dffb Q99N34 Nfkb1 Rattus norvegicus Q63369
Pull Down
16642037
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03709 DFFB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dffb NCBI NCBI:1677