ZC3H8 - zinc finger CCCH-type containing 8 Gene

Also Known as Fliz1; ZC3HDC8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84524

About ZC3H8

This gene has 6 transcripts (splice variants), 94 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 3.7), thyroid (RPKM 3.3) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in several processes, including positive regulation of thymocyte apoptotic process; regulation of transcription, DNA-templated; and snRNA transcription. Located in Cajal body; histone locus body; and transcriptionally active chromatin. Part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2022]

ZC3H8 Products (1)

mRNA	Protein	Name
NM_032494.3	NP_115883.2	zinc finger CCCH domain-containing protein 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23932780	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in T cell homeostasis	IMP IMP: Inferred from mutant phenotype	12153508	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12077251	GOA
involved in negative regulation of T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	12153508	GOA
involved in positive regulation of thymocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	12153508	GOA
involved in positive regulation of transcription by RNA polymerase III	IMP IMP: Inferred from mutant phenotype	23932780	GOA
involved in response to antibiotic	IDA IDA: Inferred from direct assay	12153508	GOA
involved in snRNA transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23932780	GOA
involved in snRNA transcription by RNA polymerase III	IMP IMP: Inferred from mutant phenotype	23932780	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Cajal body	IDA IDA: Inferred from direct assay	23932780	GOA
located in euchromatin	IDA IDA: Inferred from direct assay	23932780	GOA
located in histone locus body	IDA IDA: Inferred from direct assay	23932780	GOA
part of transcription elongation factor complex	IDA IDA: Inferred from direct assay	23932780	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZC3H8 Protein Structure

zf-CCCH

0
100
200
291 a.a.

Protein Preferred Names	Protein Names
zinc finger CCCH domain-containing protein 8	zinc finger CCCH-type domain containing 8

Related Diseases

Diseases	Alias
Villous Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15996	ZC3H8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ZC3H8	VGNC	VGNC:37110
Felis catus	ZC3H8	VGNC	VGNC:67190
Macaca mulatta	ZC3H8	VGNC	VGNC:106245
Rattus norvegicus	ZC3H8	RGD	RGD:1310458
Canis familiaris	ZC3H8	VGNC	VGNC:48562
Mus musculus	ZC3H8	MGD	MGI:1930128