TPST1 - tyrosylprotein sulfotransferase 1 Gene

Also Known as TANGO13A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8460

About TPST1

Cytogenetic location: 7q11.21 Genomic coordinates (GRCh38): 7:66,198,790-66,360,443 (from NCBI)

This gene has 6 transcripts (splice variants), 206 orthologues and 1 paralogue. Broad expression in gall bladder (RPKM 13.2), urinary bladder (RPKM 9.5) and 22 other tissues.

Summary

Enables protein homodimerization activity and protein-tyrosine sulfotransferase activity. Involved in peptidyl-tyrosine sulfation. Is integral component of Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]

TPST1 Products (1)

mRNA Protein Name
NM_003596.4 NP_003587.1 protein-tyrosine sulfotransferase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
28821720 GOA
enables protein-tyrosine sulfotransferase activity IDA
IDA: Inferred from direct assay
9501187 GOA
Biological Process GO Annotation Evidence References Source
involved in post-translational protein modification IDA
IDA: Inferred from direct assay
9501187 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
16859706 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPST1 Protein Structure

Sulfotransfer_3

Sulfotransfer_3: Sulfotransferase family (71 - 261)

  • 0
  • 100
  • 200
  • 300
  • 370 a.a.
Protein Preferred Names Protein Names

protein-tyrosine sulfotransferase 1

  • TPST-1

Recombinant TPST1 Proteins

Cat. No. Product Name Accession Purity
HY-P77255 TPST1 Protein, Human (HEK293, His) O60507 (Q26-E370) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Lung Carcinoma In Situ
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14954 TPST1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21793 Tpst1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28309 Tpst1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TPST1 VGNC VGNC:36264
Felis catus TPST1 VGNC VGNC:66487
Mus musculus TPST1 MGD MGI:1298231
Macaca mulatta TPST1 VGNC VGNC:78638
Rattus norvegicus TPST1 RGD RGD:1308473
Canis familiaris TPST1 VGNC VGNC:47755
Others TPST1 NCBI