Slc5a7 - solute carrier family 5 member 7 Gene

Rattus norvegicus

Also known as Cht1

Gene ID: 85426 | Gene type: protein coding

About Slc5a7

Summary

Enables choline transmembrane transporter activity. Involved in acetylcholine biosynthetic process. Located in several cellular components, including cytoplasmic vesicle; perikaryon; and plasma membrane raft. Biomarker of asthma. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 20 and distal hereditary motor neuronopathy type 7A. Orthologous to human SLC5A7 (solute carrier family 5 member 7). [provided by Alliance of Genome Resources, Apr 2022]

Slc5a7 Products(1)

mRNA	Protein	Name
NM_053521.2	NP_445973.2	high affinity choline transporter 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables choline transmembrane transporter activity	IDA IDA: Inferred from direct assay	10649566	RGD
enables choline transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	10649566	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17092608	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in acetylcholine biosynthetic process	IMP IMP: Inferred from mutant phenotype	10649566	RGD
involved in choline transport	IDA IDA: Inferred from direct assay	10649566	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	12628461	RGD
located in axon	IDA IDA: Inferred from direct assay	11904763	RGD
located in clathrin-coated endocytic vesicle	IDA IDA: Inferred from direct assay	15953352	RGD
located in dendrite	IDA IDA: Inferred from direct assay	11904763	RGD
located in early endosome	IDA IDA: Inferred from direct assay	15953352	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	11904763	RGD
located in plasma membrane raft	IDA IDA: Inferred from direct assay	24127780	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	20394050	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

high affinity choline transporter 1

CHT	hemicholinium-3-sensitive choline transporter
solute carrier family 5 (choline transporter), member 7	solute carrier family 5 (sodium/choline cotransporter), member 7

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13293	SLC5A7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21938	Slc5a7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc5a7	NCBI	NCBI:60482

Name
Email *

	Sorry, but the email address you supplied was invalid.