Slc5a7 - solute carrier family 5 member 7 Gene

Also Known as Cht1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 85426

Summary

Enables choline transmembrane transporter activity. Involved in acetylcholine biosynthetic process. Located in several cellular components, including cytoplasmic vesicle; perikaryon; and plasma membrane raft. Biomarker of asthma. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 20 and distal hereditary motor neuronopathy type 7A. Orthologous to human SLC5A7 (solute carrier family 5 member 7). [provided by Alliance of Genome Resources, Apr 2022]

Slc5a7 Products (1)

mRNA Protein Name
NM_053521.2 NP_445973.2 high affinity choline transporter 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables choline transmembrane transporter activity IDA
IDA: Inferred from direct assay
10649566 RGD
enables choline transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
10649566 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
17092608 RGD
Biological Process GO Annotation Evidence References Source
involved in acetylcholine biosynthetic process IMP
IMP: Inferred from mutant phenotype
10649566 RGD
involved in choline transport IDA
IDA: Inferred from direct assay
10649566 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
12628461 RGD
located in axon IDA
IDA: Inferred from direct assay
11904763 RGD
located in clathrin-coated endocytic vesicle IDA
IDA: Inferred from direct assay
15953352 RGD
located in dendrite IDA
IDA: Inferred from direct assay
11904763 RGD
located in early endosome IDA
IDA: Inferred from direct assay
15953352 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
11904763 RGD
located in plasma membrane raft IDA
IDA: Inferred from direct assay
24127780 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
20394050 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

high affinity choline transporter 1

  • CHT

  • hemicholinium-3-sensitive choline transporter

  • solute carrier family 5 (choline transporter), member 7

  • solute carrier family 5 (sodium/choline cotransporter), member 7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13293 SLC5A7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21938 Slc5a7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc5a7 NCBI NCBI:60482