SELENOI - selenoprotein I Gene

Also Known as EPT1; SELI; SEPI; SPG81

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 85465

About SELENOI

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:26,346,143-26,395,885 (from NCBI)

This gene has 4 transcripts (splice variants), 211 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 12.3), small intestine (RPKM 10.6) and 25 other tissues.

Summary

The multi-pass transmembrane protein encoded by this gene belongs to the CDP-alcohol phosphatidyltransferase class-I family. It catalyzes the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to produce phosphatidylethanolamine, which is involved in the formation and maintenance of vesicular membranes, regulation of lipid metabolism, and protein folding. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]

SELENOI Products (1)

mRNA Protein Name
NM_033505.4 NP_277040.1 ethanolaminephosphotransferase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ethanolaminephosphotransferase activity IDA
IDA: Inferred from direct assay
17132865 GOA
enables ethanolaminephosphotransferase activity IMP
IMP: Inferred from mutant phenotype
28052917 GOA
Biological Process GO Annotation Evidence References Source
involved in phosphatidylethanolamine biosynthetic process IDA
IDA: Inferred from direct assay
17132865 GOA
involved in phosphatidylethanolamine biosynthetic process IMP
IMP: Inferred from mutant phenotype
28052917 GOA
Cellular Component GO Annotation Evidence References Source
is active in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
28052917 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SELENOI Protein Structure

CDP-OH_P_transf

CDP-OH_P_transf: CDP-alcohol phosphatidyltransferase (46 - 156)

  • 0
  • 100
  • 200
  • 300
  • 397 a.a.
Protein Preferred Names Protein Names

ethanolaminephosphotransferase 1

  • ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)

Recombinant SELENOI Proteins

Cat. No. Product Name Accession Purity
HY-P70905 EPT1 Protein, Human (GST) Q9C0D9 (M1-P50) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Spastic Paraplegia 81, Autosomal Recessive

  • SPG81

  • Autosomal Recessive Complex Spastic Paraplegia Due To Kennedy Pathway Dysfunction

  • Autosomal Recessive Complex Spg Due To Kennedy Pathway Dysfunction

  • Hereditary Spastic Paraplegia 81

  • Spastic Paraplegia 81 Autosomal Recessive

  • Doid:0112349
Childhood Hepatocellular Carcinoma

  • Pediatric Hepatocellular Carcinoma

  • Childhood Carcinoma Of Liver Cell

  • Childhood Hepatoma

  • Childhood Liver Cell Carcinoma

  • Pediatric Carcinoma Of Liver Cell

  • Pediatric Hepatoma

  • Pediatric Liver Cell Carcinoma

  • Childhood-Onset Hcc

  • Childhood-Onset Hepatocellular Carcinoma

  • Pediatric Hcc

  • Childhood Liver Cancer
Spastic Paraplegia 83, Autosomal Recessive

  • SPG83

  • Hereditary Spastic Paraplegia 83

  • Spastic Paraplegia 83 Autosomal Recessive

  • Doid:0112346

  • Paraplegia, Spastic, Type 83, Autosomal Recessive
Spastic Paraplegia 82, Autosomal Recessive

  • SPG82

  • Hereditary Spastic Paraplegia 82

  • Spastic Paraplegia 82 Autosomal Recessive

  • Doid:0112343
Adult Hepatocellular Carcinoma

  • Adult Primary Hepatocellular Carcinoma

  • Adult Hepatoma

  • Adult Hcc
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Hereditary Spastic Paraplegia

  • Familial Spastic Paraplegia

  • Hereditary Spastic Paraparesis

  • Strumpell-Lorrain Disease

  • Familial Spastic Paraparesis

  • Hsp

  • Spg

  • Strümpell-Lorrain Disease

  • Spastic Paraplegia, Hereditary

  • French Settlement Disease

  • Strumpell-Lorrain Syndrome

  • Fsp

  • Spastic Paraplegia, Familial

  • Spastic Paraplegia Hereditary

  • Spastic Paraplegia 3, Autosomal Dominant

  • Spastic Paraparesis

  • Hereditary Spastic Paralysis

  • Familial Spastic Paralysis

  • Hereditary Spastic Ataxia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12636 SELENOI Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21253 Selenoi Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27770 Selenoi Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SELENOI VGNC VGNC:45982
Bos taurus SELENOI VGNC VGNC:97309
Mus musculus SELENOI MGD MGI:107898
Rattus norvegicus SELENOI RGD RGD:1560938
Macaca mulatta SELENOI VGNC VGNC:77335
Felis catus SELENOI VGNC VGNC:81218
Others SELENOI NCBI