DLEU2 - deleted in lymphocytic leukemia 2 Gene
Also Known as ALT1; DLB2; LEU2; RFP2; BCMSUN; RFP2OS; MIR15AHG; TRIM13OS; LINC00022; NCRNA00022
Species: Homo sapiens
About DLEU2
This gene has 29 transcripts (splice variants). Ubiquitous expression in bone marrow (RPKM 1.5), testis (RPKM 1.3) and 25 other tissues.
Summary
This locus represents a MicroRNA host gene and also produces long alternatively spliced non-coding RNAs. This genome region was observed to be deleted or epigenetically suppressed in leukemia, and was implicated as a negative regulator of cell proliferation. However, an alternative transcript produced at this locus was also found to promote progression through the cell cycle via angiotensin I converting enzyme 2 and cyclin D1. [provided by RefSeq, Dec 2017]
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Larynx Cancer |
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| Lymphoma |
|
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| Leukemia, Chronic Lymphocytic |
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| Pancreatic Cancer |
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| Glioma Susceptibility 1 |
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Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-P2355 | BOC-FlFlF | Antagonist | 98.31% | Unkown |
| HY-P11806 | DLeu-DTyr-Gly-DTrp-Gly-DTyr-DTrp | / | Unkown | |
| HY-P2355A | BOC-FlFlF TFA | Antagonist | / | Unkown |
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