Sfrp4 - secreted frizzled-related protein 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 89803

Summary

Enables Wnt-protein binding activity. Involved in several processes, including decidualization; mammary gland involution; and negative regulation of signal transduction. Located in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in metaphyseal dysplasia. Orthologous to human SFRP4 (secreted Frizzled related protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Sfrp4 Products (1)

mRNA Protein Name
NM_053544.2 NP_445996.2 secreted frizzled-related protein 4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Wnt-protein binding IPI
IPI: Inferred from physical interaction
18567805 RGD
Biological Process GO Annotation Evidence References Source
involved in decidualization IEP
IEP: Inferred from expression pattern
12063187 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
16540541 RGD
involved in mammary gland involution IEP
IEP: Inferred from expression pattern
9409757 RGD
involved in negative regulation of JNK cascade IDA
IDA: Inferred from direct assay
18567805 RGD
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
12952927 RGD
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
18567805 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
12063187 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
16540541 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
12960062 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
12960062 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

secreted frizzled-related protein 4

  • DDC-4 protein

  • FRP

  • frizzled related protein

  • sFRP-4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12776 SFRP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17510 Sfrp4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23967 Sfrp4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sfrp4 NCBI NCBI:6424