SFRP4 - secreted frizzled related protein 4 Gene

Also Known as PYL; FRP-4; FRPHE; FRZB-2; sFRP-4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6424

About SFRP4

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:37,905,932-37,916,817 (from NCBI)

This gene has 3 transcripts (splice variants), 152 orthologues, 15 paralogues and is associated with 55 phenotypes. Biased expression in endometrium (RPKM 325.1), ovary (RPKM 49.6) and 1 other tissue.

Summary

Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with Apoptosis related gene expression. [provided by RefSeq, Jul 2008]

SFRP4 Products (1)

mRNA	Protein	Name
NM_003014.4	NP_003005.2	secreted frizzled-related protein 4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables Wnt-protein binding	IDA IDA: Inferred from direct assay	17462603	GOA
enables Wnt-protein binding	IPI IPI: Inferred from physical interaction	17462603	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15607035	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in bone morphogenesis	IMP IMP: Inferred from mutant phenotype	27355534	GOA
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	18945944	GOA
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	18945944	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	14760084	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	14760084	GOA
involved in negative regulation of sodium-dependent phosphate transport	IDA IDA: Inferred from direct assay	12952927	GOA
involved in phosphate ion homeostasis	IDA IDA: Inferred from direct assay	12952927	GOA
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15705870	GOA
acts upstream of or within positive regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	18166153	GOA
involved in positive regulation of epidermal cell differentiation	IDA IDA: Inferred from direct assay	18938133	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	18938133	GOA
involved in positive regulation of keratinocyte apoptotic process	IDA IDA: Inferred from direct assay	18938133	GOA
involved in positive regulation of receptor internalization	IDA IDA: Inferred from direct assay	16151791	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	14760084	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11793365	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	14760084	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18938133	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SFRP4 Protein Structure

NTR

0
100
200
300
346 a.a.

Protein Preferred Names	Protein Names
secreted frizzled-related protein 4	frizzled protein, human endometrium

SFRP4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SFRP4	Q6FHJ7	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Prey Pooling	32296183
Intra	SFRP4	Q6FHJ7	HSD17B11	Homo sapiens	Q8NBQ5	Validated Y2H	32296183
Intra	SFRP4	Q6FHJ7	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Array	32296183
Intra	SFRP4	Q6FHJ7	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	SFRP4	Q6FHJ7	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	SFRP4	Q6FHJ7	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	SFRP4	Q6FHJ7	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	SFRP4	Q6FHJ7	AQP6	Homo sapiens	Q13520	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SFRP4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74551	SFRP4 Protein, Human (HEK293, His)	NP_003005.2 (A22-V346)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P74552	SFRP4 Protein, Human (CHO, His)	Q6FHJ7 (A22-V346)	≥ 95%, as determined by reducing SDS-PAGE.

SFRP4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82198	SFRP4 Antibody (YA1943)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Pyle Disease	Metaphyseal Dysplasia, Pyle Type Pyle Metaphyseal Dysplasia PYL Pyle'S Disease Metaphyseal Dysplasia Metaphyseal Dysplasia Pyle Type Pyle'S Metaphyseal Dysplasia Syndrome
Metaphyseal Dysplasia	Bakwin-Krida Syndrome Pyle'S Disease Pyle-Cohn Syndrome
Osteomalacia	Adult Rickets
Hypophosphatemia	Vitamin D-Resistant Rickets Hereditary Hypophosphatemic Rickets Vdrr Vitamin D Resistant Rickets Hypophosphatemic Rickets, X-Linked Dominant Familial Hypophosphatemic Rickets
Hyperphosphatemia
Hypophosphatemic Rickets, Autosomal Dominant	Autosomal Dominant Hypophosphatemic Rickets ADHR Autosomal Dominant Hypophosphatemia Vitamin D-Resistant Rickets, Autosomal Dominant Hypophosphatemia, Autosomal Dominant Autosomal Dominant Vitamin D-Resistant Rickets Rickets, Hypophosphatemic, Autosomal Dominant
Hypophosphatasia	Phosphoethanolaminuria Childhood Hypophosphatasia Deficiency Of Alkaline Phosphatase Hypophospatasia, Childhood Hypophosphatasia Mild Phosphoethanol-Aminuria Rathburn Disease Hpp Rathbun Disease Hypophosphatasia, Childhood Infantile Hypophosphatasia
Hypophosphatemic Rickets, X-Linked Recessive	Hypophosphatemic Rickets X-Linked Recessive Hypophosphatemic Rickets XLRHR Hypophosphatemic Rickets Disorders Rickets Hypophosphatemic Rickets, Hypophosphatemic, X-Linked Recessive Familial Hypophosphatemic Rickets
Ureteral Obstruction
Craniodiaphyseal Dysplasia	CDD Schaefer Stein Oshman Syndrome Craniodiaphyseal Dysplasia, Dominant Dominantly Inherited Craniodiaphyseal Dysplasia
Ulna And Fibula, Absence Of, With Severe Limb Deficiency	Schinzel Phocomelia Syndrome Aarrs Limb/Pelvis-Hypoplasia/Aplasia Syndrome LPHAS Schinzel Type Phocomelia Absence Of Ulna And Fibula With Severe Limb Deficiency Al-Awadi/Raas-Rothschild Syndrome Al Awadi-Raas-Rothschild Syndrome Al-Awadi/Raas-Rothschild/Schinzel Phocomelia Syndrome Aplasia/Hypoplasia Of Limbs And Pelvis Congenital Absence Of Ulna And Fibula Severe Limb Deficit Phocomelia, Schinzel Type Al-Awadi-Raas-Rothschild Syndrome Ulna And Fibula Absence Of With Severe Limb Deficiency Limb Pelvis Hypoplasia Aplasia Syndrome Limb/Pelvis/Uterus-Hypoplasia/Aplasia Syndrome Ulna And Fibula, Absence Of, With Sever Limb Deficiency
Prostate Signet Ring Cell Adenocarcinoma	Prostate Signet Ring Cell Carcinoma Signet Ring Cell Carcinoma Of Prostate Acinar Prostate Adenocarcinoma, Signet Ring Variant
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Autosomal Recessive Hypophosphatemic Rickets	Arhr Hypophosphatemic Rickets, Autosomal Recessive Autosomal Recessive Hypophosphatemic Vitamin D Refractory Rickets
Van Buchem Disease	Hyperostosis Corticalis Generalisata Hyperphosphatasemia Tarda VBCH Sost-Related Sclerosing Bone Dysplasia Endosteal Hyperostosis Autosomal Recessive Sclerosteosis Endosteal Hyperostosis, Autosomal Recessive Hyperotosis Corticalis Generalisata Familiaris Sost Sclerosing Bone Dysplasia Smith-Lemli-Opitz Syndrome
Sclerosteosis	Cortical Hyperostosis With Syndactyly Sost Cortical Hyperostosis-Syndactyly Syndrome
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Endosteal Hyperostosis, Autosomal Dominant	Osteosclerosis Worth Syndrome Osteosclerosis, Autosomal Dominant Hyperostosis, Endosteal Endosteal Hyperostosis, Worth Type Worth Disease Autosomal Dominant Endosteal Hyperostosis Autosomal Dominant Osteosclerosis, Worth Type Hyperostosis Corticalis Generalisata, Benign Form Of Worth, With Torus Palatinus Autosomal Dominant Osteosclerosis Benign Form Of Worth Hyperostosis Corticalis Generalisata With Torus Platinus Worth'S Syndrome Worth Type Autosomal Dominant Osteosclerosis Hyperostosis Corticalis Generalisata, Benign Form Of Worth With Torus Palatinus Osteosclerosis, Autosomal Dominant, Worth Type WENHY Endosteal Hyperostosis Autosomal Dominant Hyperostosis Corticalis Generalisata Benign Form Of Worth With Torus Palatinus Osteosclerosis Autosomal Dominant Acquired Osteosclerosis
Hypophosphatemic Rickets, X-Linked Dominant	X-Linked Hypophosphatemia Xlh Vitamin D-Resistant Rickets, X-Linked X-Linked Hypophosphatemic Rickets XLHR Hyp Hypophosphatemic Vitamin D-Resistant Rickets Hpdr X-Linked Dominant Hypophosphatemic Rickets Familial Hypophosphatemic Rickets Hypophosphatemia, X-Linked Hypophosphatemia, Vitamin D-Resistant Rickets Hypophosphatemic Rickets X-Linked Dominant X-Linked Vitamin D-Resistant Rickets Hypophophatemia, X-Linked Hypophophatemic Vitamin D-Resistant Rickets Hypophosphatemia X-Linked Vitamin D-Resistant Rickets X-Linked Vitamin D-Resistant Rickets Rickets, X-Linked Hypophosphatemic
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Robinow Syndrome	Acral Dysostosis With Facial And Genital Abnormalities Fetal Face Syndrome Robinow Dwarfism Mesomelic Dwarfism-Small Genitalia Syndrome Robinow-Silverman-Smith Syndrome Costovertebral Segmentation Defect With Mesomelia Covesdem Syndrome Robinow'S Syndrome Robinow-Silverman Syndrome
Brittle Bone Disorder	Osteogenesis Imperfecta Brittle Bone Disease Fragilitas Ossium Osteopsathyrosis Lobstein Disease Oi Vrolik Disease Lobstein'S Disease Lobstein'S Syndrome Vrolik'S Disease Porak And Durante Disease Glass Bone Disease Osteogenesis Imperfecta, Dominant Perinatal Lethal Osteogenesis Imperfecta, Recessive Perinatal Lethal Brittle Bone Syndrome Oi - [Osteogenesis Imperfecta] Ossium Fragility Osteitis Fragilitans Bony Fragility Blue Sclera With Fragility Of Bone And Deafness White Blue Sclera - Fragility Of Bone - Deafness
Osteochondrodysplasia	Skeletal Dysplasia Chondrodystrophy Congenital Anomaly Of Cartilage Osteochondrodysplasias Cartilage Development Disorder Osteochondrodysplasia Syndrome Dysplasia, Skeletal Mucopolysaccharidosis Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12776	SFRP4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17510	Sfrp4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23967	Sfrp4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SFRP4	VGNC	VGNC:34522
Rattus norvegicus	SFRP4	RGD	RGD:621075
Mus musculus	SFRP4	MGD	MGI:892010
Felis catus	SFRP4	VGNC	VGNC:65064
Canis familiaris	SFRP4	VGNC	VGNC:46082
Macaca mulatta	SFRP4	VGNC	VGNC:77187
Others	SFRP4	NCBI