PLCZ1 - phospholipase C zeta 1 Gene

Also Known as SPGF17; PLCzeta; NYD-SP27; PLC-zeta-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 89869

About PLCZ1

Cytogenetic location: 12p12.3 Genomic coordinates (GRCh38): 12:18,645,609-18,738,012 (from NCBI)

This gene has 20 transcripts (splice variants), 203 orthologues, 14 paralogues and is associated with 1 phenotype. Restricted expression toward testis (RPKM 5.9).

Summary

The protein encoded by this gene is a member of the phosphoinositide-specific Phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits CA(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

PLCZ1 Products (3)

mRNA	Protein	Name
NM_001330769.1	NP_001317698.1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform 3
NM_001330774.2	NP_001317703.1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform 2
NM_033123.4	NP_149114.2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform 1

PLCZ1 Protein Structure

EF-hand_like

PI-PLC-X

PI-PLC-Y

C2

0
100
200
300
400
500
608 a.a.

Protein Preferred Names	Protein Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1	PI-phospholipase C zeta 1

Related Diseases

Diseases	Alias
Spermatogenic Failure 17	SPGF17 Male Infertility Due To Oocyte Activation Failure
Spermatogenic Failure 9	Male Infertility Due To Globozoospermia SPGF9 Male Infertility Due To Round-Headed Spermatozoa Globozoospermia, Complete Globozoospermia, Total Globozoospermia Globozoospermia Syndrome Round-Headed Sperm Syndrome Globozoospermia Complete Globozoospermia Total
Infertility
Varicocele	Scrotal Varices Varicoceles Varicocele Of Scrotum Scrotal Varicocele
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Warburg Micro Syndrome 1	Warburg Micro Syndrome Micro Syndrome Warbm WARBM1 Warburg Sjo Fledelius Syndrome Warburg-Sjo-Fledelius Syndrome Micro Syndrome 1 Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism
Oligoasthenoteratozoospermia	Oat Oligoasthenoteratospermia
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10669	PLCZ1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PLCZ1	RGD	RGD:1359567
Macaca mulatta	PLCZ1	VGNC	VGNC:76070
Felis catus	PLCZ1	VGNC	VGNC:64212
Canis familiaris	PLCZ1	VGNC	VGNC:44659
Mus musculus	PLCZ1	MGD	MGI:2150308
Bos taurus	PLCZ1	VGNC	VGNC:32995
Others	PLCZ1	NCBI