MTRFR - mitochondrial translation release factor in rescue Gene

Also Known as SPG55; COXPD7; mtRF-R; C12orf65

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 91574

Summary

This nuclear gene encodes a mitochondrial matrix protein that appears to contribute to peptide chain termination in the mitochondrial translation machinery. Two different 1 bp deletions (resulting in the same premature stop codon)result in decreased mitochondrial translation, decreased levels of Oxidative Phosphorylation complexes and encepthalomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

MTRFR Products (1)

mRNA Protein Name
NM_001143905.2 NP_001137377.1 mitochondrial translation release factor in rescue

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
enables ribosomal large subunit binding IDA
IDA: Inferred from direct assay
33243891 GOA
enables tRNA binding IDA
IDA: Inferred from direct assay
33243891 GOA
Biological Process GO Annotation Evidence References Source
involved in rescue of stalled ribosome IDA
IDA: Inferred from direct assay
33243891 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
20186120 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitochondrial translation release factor in rescue

  • probable peptide chain release factor C12orf65, mitochondrial

MTRFR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MTRFR Q9H3J6 MYLK2 Homo sapiens Q9H1R3
Anti Tag CoIP
33961781
Intra
MTRFR Q9H3J6 MYLK2 Homo sapiens Q9H1R3
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08778 MTHFR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08769 MTFR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08770 MTFR1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08771 MTFR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08817 MTRF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08818 MTRF1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08819 MTRR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20057 Mthfr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26561 Mthfr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown