CER1 - cerberus 1, DAN family BMP antagonist Gene

Also Known as DAND4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9350

About CER1

Cytogenetic location: 9p22.3 Genomic coordinates (GRCh38): 9:14,717,326-14,722,733 (from NCBI)

This gene has 1 transcript (splice variant), 125 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]

CER1 Products (1)

mRNA	Protein	Name
NM_005454.3	NP_005445.1	cerberus precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables BMP binding	IDA IDA: Inferred from direct assay	9660951	GOA
enables morphogen activity	IDA IDA: Inferred from direct assay	9660951	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in bone mineralization	IMP IMP: Inferred from mutant phenotype	19113921	GOA
involved in determination of dorsal identity	IMP IMP: Inferred from mutant phenotype	9660951	GOA
involved in negative regulation of activin receptor signaling pathway	IDA IDA: Inferred from direct assay	9660951	GOA
involved in negative regulation of mesoderm development	IMP IMP: Inferred from mutant phenotype	9660951	GOA
involved in nervous system development	IMP IMP: Inferred from mutant phenotype	9660951	GOA
involved in sequestering of BMP in extracellular matrix	IDA IDA: Inferred from direct assay	9660951	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CER1 Protein Structure

DAN

0
100
200
267 a.a.

Protein Preferred Names	Protein Names
cerberus	DAN domain family member 4

Recombinant CER1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7822	Cerberus 1/CER1 Protein, Human (HEK293, His)	AAI03977.1 (T18-A267)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75350	Cerberus 1/CER1 Protein, Human (sf9, His)	AAH69371.1 (T18-A267)	≥ 80%, as determined by reducing SDS-PAGE.

CER1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85099	Cerberus Antibody (YA4791)	WB, IHC-P, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Chromosome 9p Deletion Syndrome	Monosomy 9p Monosomy 9p Syndrome Alfi Syndrome 9p Syndrome Chromosome 9p Deletion 9p Deletion 9p Monosomy Deletion 9p Partial Monosomy 9p 9p Deletion Syndrome 9p- Syndrome Alfi'S Syndrome Chromosome 9, Partial Trisomy 9p
Cardiomyopathy, Dilated, 1x	Dilated Cardiomyopathy 1x CMD1X Dilated Cardiomyopathy With Mild Or No Proximal Muscle Weakness Cardiomyopathy, Dilated, With Mild Or No Proximal Muscle Weakness Cardiomyopathy, Dilated 1x Cardiomyopathy, Dilated, Type 1x
Anisometropia
Kleefstra Syndrome 1	9q Subtelomeric Deletion Syndrome KLEFS1 Chromosome 9q34.3 Deletion Syndrome 9q- Syndrome 9q34 Deletion Syndrome Kleefstra Syndrome Due To 9q34 Microdeletion Kleefstra Syndrome 9q-Syndrome 9qstds Kleefstra Syndrome Due To 9q Subtelomeric Deletion Kleefstra Syndrome Due To Del(9)(Q34) Kleefstra Syndrome Due To Monosomy 9q34 Chromosome 9q Subtelomeric Deletion Syndrome Kleefstra Syndrome, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-126015	P053	Inhibitor	97.0%	Unkown
HY-120803	Mefluidide		99.81%	Unkown
HY-146910S	CER1 (d18:1/26:0/18:1)-d9		99.0%	Unkown
HY-176568	LCL768		/	Unkown
HY-N15835	CER1(d18:1/28:0/18:2)		/	Unkown
HY-RS02532	CER1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02536	CERS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-175198	Cs-2d	Inhibitor	/	Unkown
HY-179832	CER1 (d18:1/26:0/18:1)		/	Unkown
HY-RS18128	Cer1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19995	Cers1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24602	Cer1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26499	Cers1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CER1	MGD	MGI:1201414
Bos taurus	CER1	VGNC	VGNC:27221
Rattus norvegicus	CER1	RGD	RGD:1563046
Felis catus	CER1	VGNC	VGNC:102913
Macaca mulatta	CER1	VGNC	VGNC:71011
Canis familiaris	CER1	VGNC	VGNC:39145
Others	CER1	NCBI