Cerberus 1/CER1 Protein, Human (sf9, His)

The Cerberus 1/CER1 protein emerges as a cytokine that may be involved in preneural induction and somite formation during embryogenesis, in part through its inhibitory effect on BMP signaling. Its regulatory role extends into gastrulation, where it can influence nodal signaling and contribute to primitive streak formation and patterning. Cerberus 1/CER1 Protein, Human (sf9, His) is the recombinant human-derived Cerberus 1/CER1 protein, expressed by Sf9 insect cells , with C-His labeled tag.

Cerberus 1 (CER1) is a cytokine with potential significance in embryonic development, particularly in anterior neural induction and somite formation. Its involvement is attributed, at least in part, to its inhibitory action on BMP (bone morphogenetic protein). CER1 exhibits a regulatory role in Nodal signaling during gastrulation and contributes to the formation and patterning of the primitive streak, suggesting its multifaceted influence on early developmental processes. Structurally, CER1 is known to form monomers and predominantly exists as dimers, indicating its dynamic molecular organization. The ability of CER1 to modulate key signaling pathways and participate in embryogenesis underscores its importance in orchestrating complex developmental events.

Human

Sf9 insect cells

C-His

AAH69371.1 (T18-A267)

9350  [NCBI]

Full Length

TWHQDGRQNQSSLSPVLLPRNQRELPTGNHEEAEEKPDLFVAVPHLVGTSPAGEGQRQREKMLSRFGRFWKKPEREMHPSRDSDSEPFPPGTQSLIQPIDGMKMEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHEVHWETCRTVPFSQTITHEGCEKIVVQNNLCFGKCGSVHFPGAAQHSHTSCSHCLPAKFTTMHLPLNCTELSSVIKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA

≥ 80%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.