Cerberus 1/CER1 Protein, Human (sf9, His)
The Cerberus 1/CER1 protein emerges as a cytokine that may be involved in preneural induction and somite formation during embryogenesis, in part through its inhibitory effect on BMP signaling. Its regulatory role extends into gastrulation, where it can influence nodal signaling and contribute to primitive streak formation and patterning. Cerberus 1/CER1 Protein, Human (sf9, His) is the recombinant human-derived Cerberus 1/CER1 protein, expressed by Sf9 insect cells , with C-His labeled tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
The Cerberus 1/CER1 protein emerges as a cytokine that may be involved in preneural induction and somite formation during embryogenesis, in part through its inhibitory effect on BMP signaling. Its regulatory role extends into gastrulation, where it can influence nodal signaling and contribute to primitive streak formation and patterning. Cerberus 1/CER1 Protein, Human (sf9, His) is the recombinant human-derived Cerberus 1/CER1 protein, expressed by Sf9 insect cells , with C-His labeled tag.
Background
Cerberus 1 (CER1) is a cytokine with potential significance in embryonic development, particularly in anterior neural induction and somite formation. Its involvement is attributed, at least in part, to its inhibitory action on BMP (bone morphogenetic protein). CER1 exhibits a regulatory role in Nodal signaling during gastrulation and contributes to the formation and patterning of the primitive streak, suggesting its multifaceted influence on early developmental processes. Structurally, CER1 is known to form monomers and predominantly exists as dimers, indicating its dynamic molecular organization. The ability of CER1 to modulate key signaling pathways and participate in embryogenesis underscores its importance in orchestrating complex developmental events.
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag C-His
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Accession
AAH69371.1 (T18-A267)
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Molecular Construction
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N-term
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CER1 (T18-A267)
Accession # AAH69371.1 -
His
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C-term
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Protein Length
Full Length
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Synonyms
CER1; DAN Domain Family Member 4; Cerberus 1, DAN Family BMP Antagonist; Cerberus 1 (Xenopus Laevis) Homolog (Cysteine Knot Superfamily); DAND4; Cerberus 1, Cysteine Knot Superfamily, Homolog (Xenopus Laevis); Cerberus-Related Protein; Cerberus 1, Cystein
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AA Sequence
TWHQDGRQNQSSLSPVLLPRNQRELPTGNHEEAEEKPDLFVAVPHLVGTSPAGEGQRQREKMLSRFGRFWKKPEREMHPSRDSDSEPFPPGTQSLIQPIDGMKMEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHEVHWETCRTVPFSQTITHEGCEKIVVQNNLCFGKCGSVHFPGAAQHSHTSCSHCLPAKFTTMHLPLNCTELSSVIKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA
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Predicted Molecular Mass
29.6 kDa
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Glycosylation
Yes
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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