Trim6 - tripartite motif-containing 6 Gene

Mus musculus

Also known as D7Ertd684e; C430046K18Rik

Gene ID: 94088 | Gene type: protein coding

About Trim6

Summary

Enables DNA-binding transcription factor binding activity and protein kinase binding activity. Involved in several processes, including negative regulation of viral genome replication; positive regulation of type I interferon-mediated signaling pathway; and regulation of gene expression. Located in cytosol and nucleus. Is expressed in testis. Orthologous to human TRIM6 (tripartite motif containing 6). [provided by Alliance of Genome Resources, Apr 2022]

Trim6 Products(1)

mRNA	Protein	Name
NM_001013616.2	NP_001013637.1	tripartite motif-containing protein 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	22328504	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11331580	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	24882218	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to virus	IDA IDA: Inferred from direct assay	24882218	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	22328504	MGI
involved in negative regulation of stem cell differentiation	IMP IMP: Inferred from mutant phenotype	22328504	MGI
involved in negative regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	24882218	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22328504	MGI
involved in positive regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	24882218	MGI
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	22328504	MGI
NOT involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	22328504	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11331580	MGI
located in cytosol	IMP IMP: Inferred from mutant phenotype	22328504	MGI
located in nucleus	IMP IMP: Inferred from mutant phenotype	22328504	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tripartite motif-containing protein 6

RING-type E3 ubiquitin transferase TRIM6

tripartite motif protein 6

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15060	TRIM6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trim6	NCBI	NCBI:117854

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