Madd - MAP-kinase activating death domain Gene

Also Known as RabGEF; RabGEP

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 94193

Summary

Enables guanyl-nucleotide exchange factor activity. Involved in negative regulation of growth hormone secretion and negative regulation of pancreatic amylase secretion. Located in cytosol; nucleus; and synaptic vesicle. Is active in synapse. Biomarker of transient cerebral ischemia. Orthologous to human MADD (MAP kinase activating death domain). [provided by Alliance of Genome Resources, Apr 2022]

Madd Products (1)

mRNA Protein Name
NM_053585.2 NP_446037.1 MAP kinase-activating death domain protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
9224661 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12786944 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of growth hormone secretion IDA
IDA: Inferred from direct assay
16473592 RGD
involved in negative regulation of pancreatic amylase secretion IMP
IMP: Inferred from mutant phenotype
23702376 RGD
Cellular Component GO Annotation Evidence References Source
is active in synapse IDA
IDA: Inferred from direct assay
9852129 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
12786944 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

MAP kinase-activating death domain protein

  • Rab3 GDP/GTP exchange protein

  • rab3 GDP/GTP exchange factor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-G0016 N-Acetyl dapsone / Unkown
HY-RS04555 ETFA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04556 ETFB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04557 ETFDH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07953 MADD Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Madd NCBI NCBI:8567