Maged1 - MAGE family member D1 Gene

Also Known as NRAGE; Dlixin; Dlxin1; Dlxin-1; MAGE-D1; DXBwg1492e; 2810433C11Rik; 5430405L04Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 94275

Summary

Enables transcription coactivator activity. Involved in several processes, including positive regulation of MAP kinase activity; positive regulation of branching involved in ureteric bud morphogenesis; and regulation of gene expression. Acts upstream of or within negative regulation of protein localization to nucleus; positive regulation of apoptotic signaling pathway; and regulation of transcription by RNA polymerase II. Located in chromatin and nucleus. Is expressed in several structures, including alimentary system; egg cylinder; genitourinary system; hair follicle; and nervous system. Orthologous to human MAGED1 (MAGE family member D1). [provided by Alliance of Genome Resources, Apr 2022]

Maged1 Products (1)

mRNA	Protein	Name
NM_019791.3	NP_062765.1	melanoma-associated antigen D1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11084035	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	11084035	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20300063	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19268530	MGI
acts upstream of or within negative regulation of protein localization to nucleus	IDA IDA: Inferred from direct assay	17488777	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19268530	MGI
involved in positive regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	19268530	MGI
acts upstream of or within positive regulation of apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	17488777	MGI
acts upstream of or within positive regulation of apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	19268530	MGI
involved in positive regulation of branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	19268530	MGI
acts upstream of protein localization to nucleus	IDA IDA: Inferred from direct assay	17488777	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	20300063	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11084035	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	20300063	MGI
located in nucleus	IDA IDA: Inferred from direct assay	20300063	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
melanoma-associated antigen D1	MAGE-D1 antigen melanoma antigen, family D, 1 neurotrophin receptor-interacting MAGE homolog

Maged1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Maged1	Q9QYH6	Rora	Mus musculus	P51448	Anti Bait CoIP	20300063
Intra	Maged1	Q9QYH6	Rora	Mus musculus	P51448	Anti Tag CoIP	20300063
Intra	Maged1	Q9QYH6	Ndn	Mus musculus	P25233	Anti Bait CoIP	15272023
Intra	Maged1	Q9QYH6	Ndn	Mus musculus	P25233	Pull Down	15272023
Intra	Maged1	Q9QYH6	Dlx5	Mus musculus	P70396	Anti Tag CoIP	11084035
Intra	Maged1	Q9QYH6	Msx2	Mus musculus	Q03358	Anti Bait CoIP	15272023
Intra	Maged1	Q9QYH6	Msx2	Mus musculus	Q03358	Anti Tag CoIP	11959851
Intra	Maged1	Q9QYH6	Pja1	Mus musculus	O55176-2	Y2H	11959851
Intra	Maged1	Q9QYH6	Pja1	Mus musculus	O55176-2	Anti Tag CoIP	11959851

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07976	MAGED1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Maged1	NCBI	NCBI:9500