GTPBP1 - GTP binding protein 1 Gene

Also Known as GP1; GP-1; HSPC018

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9567

About GTPBP1

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,705,944-38,743,115 (from NCBI)

This gene has 13 transcripts (splice variants), 204 orthologues and 18 paralogues. Ubiquitous expression in bone marrow (RPKM 26.4), spleen (RPKM 10.5) and 25 other tissues.

Summary

This gene is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. A structurally similar protein has been found in mouse, where disruption of the gene for that protein had no observable phenotype. [provided by RefSeq, Jul 2008]

GTPBP1 Products (1)

mRNA Protein Name
NM_004286.5 NP_004277.2 GTP-binding protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables GTPase activity IDA
IDA: Inferred from direct assay
30108131 GOA
enables alpha-aminoacyl-tRNA binding IDA
IDA: Inferred from direct assay
30108131 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables tRNA binding IDA
IDA: Inferred from direct assay
30108131 GOA
enables translation elongation factor activity IDA
IDA: Inferred from direct assay
30108131 GOA
Biological Process GO Annotation Evidence References Source
involved in cytoplasmic translation IDA
IDA: Inferred from direct assay
30108131 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GTPBP1 Protein Structure

GTP_EFTU

GTP_EFTU: Elongation factor Tu GTP binding domain (161 - 383)

GTP_EFTU_D2

GTP_EFTU_D2: Elongation factor Tu domain 2 (409 - 479)

GTP_EFTU_D3

GTP_EFTU_D3: Elongation factor Tu C-terminal domain (486 - 573)

  • 0
  • 200
  • 400
  • 600
  • 669 a.a.
Protein Preferred Names Protein Names

GTP-binding protein 1

  • G-protein 1

GTPBP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GTPBP1 O00178 C7orf25 Homo sapiens Q9BPX7
Validated Y2H
32296183
Intra
GTPBP1 O00178 C7orf25 Homo sapiens Q9BPX7
Y2H Prey Pooling
32296183
Intra
GTPBP1 O00178 C7orf25 Homo sapiens Q9BPX7
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Argentine Hemorrhagic Fever

  • Argentinian Hemorrhagic Fever

  • Junin Hemorrhagic Fever

  • Hemorrhagic Fever, Argentinian

  • Ahf - [Argentinian Haemorrhagic Fever]

  • Argentine Haemorrhagic Fever

  • Junin Haemorrhagic Fever
Bolivian Hemorrhagic Fever

  • Machupo Hemorrhagic Fever

  • Hemorrhagic Fever, Bolivian

  • Bhf - [Bolivian Haemorrhagic Fever]

  • Machupo Haemorrhagic Fever
Marburg Hemorrhagic Fever

  • Marburg Virus Disease

  • Marburg Disease

  • Green Monkey Disease

  • Mhf

  • Vervet Monkey Disease

  • Mard - [Marburg Disease]

  • Mvd - [Marburg Virus Disease]

  • Marburg Haemorrhagic Fever

  • Mhf - [Marburg Haemorrhagic Fever]
Venezuelan Hemorrhagic Fever

  • Guanarito Hemorrhagic Fever

  • Vehf - [Venezuelan Haemorrhagic Fever]
Brazilian Hemorrhagic Fever

  • Sabia Hemorrhagic Fever
Ebola Hemorrhagic Fever

  • Ebola Virus Disease

  • Viral Hemorrhagic Fever

  • Hemorrhagic Fever, Ebola

  • Ebola

  • Ehf

  • Ebola Fever

  • Hemorrhagic Fevers, Viral

  • Ebola Haemorrhagic Fever

  • Ebod - [Ebola Disease]

  • Evd - [Ebola Virus Disease]

  • Ebola Virus Haemorrhagic Fever

  • Vhf - [Viral Haemorrhagic Fever] Nos

  • Viral Haemorrhagic Fever, Not Otherwise Specified
Lassa Fever

  • Lf

  • Lassa Hemorrhagic Fever

  • Lf - [Lassa Fever]
Lujo Hemorrhagic Fever

  • Zambian Hemorrhagic Fever
Klippel-Feil Syndrome 4
Blessig'S Cysts

  • Microcystoid Retinal Degeneration

  • Blessig Cysts

  • Iwanoff'S Cysts

  • Microcystoid Degeneration Of Retina
De Quervain Disease

  • Radial Styloid Tenosynovitis

  • Tenosynovitis, De Quervain'S

  • De Quervain'S Disease

  • Tenosynovitis Of Radial Styloid Process

  • Stenosans Tenosynovitis
Immature Cataract

  • Incipient Cataract

  • Incipient Senile Cataract

  • Water Clefts
Crimean-Congo Hemorrhagic Fever

  • Crimean Hemorrhagic Fever

  • Cchf

  • Congo Hemorrhagic Fever

  • Hemorrhagic Fever, Crimean

  • Chf Congo Virus

  • Congo-Crimean Hemorrhagic Fever

  • Congo Fever

  • Hemorrhagic Fever Crimean-Congo

  • Cchf - [Crimean-Congo Haemorrhagic Fever]

  • Kara Mikh Typhoid Fever

  • Xīnjiāng Haemorrhagic Fever
Hemochromatosis, Type 1

  • Hemochromatosis

  • Hemochromatosis Type 1

  • Hereditary Hemochromatosis

  • Hh

  • HFE1

  • Hfe Hemochromatosis, Modifier Of

  • Symptomatic Form Of Classic Hemochromatosis

  • Symptomatic Form Of Hemochromatosis Type 1

  • Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

  • Haemochromatosis

  • Iron Storage Disorder

  • Bronze Diabetes

  • Hereditary Haemochromatosis

  • Hlah

  • Hfe

  • Hemochromatosis, Hereditary

  • Diabetes Bronze

  • Classic Hemochromatosis

  • Hfe-Associated Hereditary Hemochromatosis

  • Hemochromatosis Classic

  • Bronzed Cirrhosis

  • Familial Hemochromatosis

  • Genetic Hemochromatosis

  • Hc

  • Pigmentary Cirrhosis

  • Primary Hemochromatosis

  • Troisier-Hanot-Chauffard Syndrome

  • Von Recklenhausen-Applebaum Disease

  • Hemochromatosis 1

  • Primary Hereditary Hemochromatosis

  • Bronze Cirrhosis
Stuttering

  • Stammering

  • Familial Persistent Stuttering

  • Stuttering, Familial Persistent 1
Niemann-Pick Disease, Type C1

  • Niemann-Pick Disease, Type C

  • NPC1

  • Niemann-Pick Disease, Type D

  • Niemann-Pick Disease Type C1

  • Niemann-Pick Disease With Cholesterol Esterification Block

  • Niemann-Pick Disease, Subacute Juvenile Form

  • Neurovisceral Storage Disease With Vertical Supranuclear Ophthalmoplegia

  • Npc

  • Niemann-Pick Disease, Chronic Neuronopathic Form

  • Niemann-Pick Disease Without Sphingomyelinase Deficiency

  • Niemann-Pick Disease Type C

  • Niemann-Pick Disease Type D

  • Niemann-Pick C1 Disease

  • Niemann-Pick Disease C1

  • Niemann-Pick Disease Chronic Neuronopathic Form

  • Niemann-Pick Disease Nova Scotian Type

  • Niemann-Pick Disease Subacute Juvenile Form

  • Niemann-Pick Disease Type Ii

  • Niemann-Picks Disease Type C
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05908 GTPBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GTPBP1 VGNC VGNC:67507
Mus musculus GTPBP1 MGD MGI:109443
Rattus norvegicus GTPBP1 RGD RGD:1306758
Canis familiaris GTPBP1 VGNC VGNC:41557
Bos taurus GTPBP1 VGNC VGNC:29708
Macaca mulatta GTPBP1 VGNC VGNC:73320
Others GTPBP1 NCBI