ENTPD4 - ectonucleoside triphosphate diphosphohydrolase 4 Gene

Also Known as LAP70; LALP70; LYSAL1; UDPase; NTPDase-4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9583

About ENTPD4

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:23,429,162-23,457,647 (from NCBI)

This gene has 11 transcripts (splice variants), 212 orthologues and 7 paralogues. Ubiquitous expression in lymph node (RPKM 16.0), appendix (RPKM 14.8) and 25 other tissues.

Summary

This gene encodes a member of the apyrase protein family. Apyrases are Enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium-dependent manner. The encoded protein is an endo-apyrase and may play a role in salvaging nucleotides from lysosomes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and these isoforms may differ in divalent cation dependence and substrate specificity. [provided by RefSeq, Sep 2011]

ENTPD4 Products (2)

mRNA	Protein	Name
NM_001128930.3	NP_001122402.1	ectonucleoside triphosphate diphosphohydrolase 4 isoform b
NM_004901.5	NP_004892.1	ectonucleoside triphosphate diphosphohydrolase 4 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables CDP phosphatase activity	IDA IDA: Inferred from direct assay	10858452	GOA
enables CTPase activity	IDA IDA: Inferred from direct assay	10858452	GOA
enables GDP phosphatase activity	IDA IDA: Inferred from direct assay	10858452	GOA
enables UDP phosphatase activity	IDA IDA: Inferred from direct assay	9556635	GOA
enables nucleoside diphosphate phosphatase activity	IDA IDA: Inferred from direct assay	10858452	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	33961781	GOA
enables ribonucleoside triphosphate phosphatase activity	IDA IDA: Inferred from direct assay	10858452	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in CTP metabolic process	IDA IDA: Inferred from direct assay	10858452	GOA
involved in GDP catabolic process	IDA IDA: Inferred from direct assay	10858452	GOA
involved in UDP catabolic process	IDA IDA: Inferred from direct assay	9556635	GOA
involved in nucleobase-containing small molecule catabolic process	IDA IDA: Inferred from direct assay	10858452	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	9556635	GOA
located in autophagosome membrane	IDA IDA: Inferred from direct assay	10393803	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENTPD4 Protein Structure

GDA1_CD39

0
100
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300
400
500
616 a.a.

Protein Preferred Names	Protein Names
ectonucleoside triphosphate diphosphohydrolase 4	Golgi UDPase

ENTPD4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ENTPD4	Q9Y227	PCYOX1	Homo sapiens	Q9UHG3	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Autosomal Recessive Intellectual Developmental Disorder	Mental Retardation, Autosomal Recessive Autosomal Recessive Mental Retardation Autosomal Recessive Non-Syndromic Mental Retardation Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04398	ENTPD4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ENTPD4	VGNC	VGNC:56947
Rattus norvegicus	ENTPD4	RGD	RGD:1309511
Canis familiaris	ENTPD4	VGNC	VGNC:40383
Felis catus	ENTPD4	VGNC	VGNC:61881
Others	ENTPD4	NCBI