SH3PXD2A - SH3 and PX domains 2A Gene

Homo sapiens

Also known as FISH; TKS5; SH3MD1

Gene ID: 9644 | Gene type: protein coding

About SH3PXD2A

Cytogenetic location: 10q24.33 Genomic coordinates (GRCh38): 10:103,594,027-103,855,576 (from NCBI)

This gene has 7 transcripts (splice variants), 263 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in endometrium (RPKM 4.2), ovary (RPKM 3.4) and 25 other tissues.

Summary

Predicted to enable superoxide-generating NADPH Oxidase activator activity. Involved in osteoclast fusion and superoxide metabolic process. Located in podosome. [provided by Alliance of Genome Resources, Apr 2022]

SH3PXD2A Products(11)

mRNA	Protein	Name
NM_001365079.1	NP_001352008.1	SH3 and PX domain-containing protein 2A isoform 2
NM_001394015.1	NP_001380944.1	SH3 and PX domain-containing protein 2A isoform 3
NM_001394016.1	NP_001380945.1	SH3 and PX domain-containing protein 2A isoform 4
NM_001394017.1	NP_001380946.1	SH3 and PX domain-containing protein 2A isoform 5
NM_001394018.1	NP_001380947.1	SH3 and PX domain-containing protein 2A isoform 6
NM_001394019.1	NP_001380948.1	SH3 and PX domain-containing protein 2A isoform 7
NM_001394020.1	NP_001380949.1	SH3 and PX domain-containing protein 2A isoform 8
NM_001394021.1	NP_001380950.1	SH3 and PX domain-containing protein 2A isoform 9
NM_001394022.1	NP_001380951.1	SH3 and PX domain-containing protein 2A isoform 10
NM_001394023.1	NP_001380952.1	SH3 and PX domain-containing protein 2A isoform 10
NM_014631.3	NP_055446.2	SH3 and PX domain-containing protein 2A isoform 1

SH3PXD2A Protein Structure

SH3_1

0
200
400
600
800
1000
1133 a.a.

Protein Preferred Names

Protein Names

SH3 and PX domain-containing protein 2A

SH3 multiple domains 1

Recombinant SH3PXD2A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71572	SH3PXD2A Protein, Human (Myc, His)	Q5TCZ1 (902P-986P)	≥95%

Related Diseases

Diseases

Alias

Malignant Triton Tumor

Malignant Peripheral Nerve Sheath Neoplasm With Rhabdomyosarcoma	Malignant Triton Tumour
Mpnst With Rhabdomyoblastic Differentiation	Mpnst With Rhabdomyosarcoma
Mpnst With Rhabdomyosarcomatous Differentiation	Mtt
Malignant Peripheral Nerve Sheath Tumor With Rhabdomyosarcomatous Differenciation	Malignant Peripheral Nerve Sheath Tumor With Rhabdomyoblastic Differentiation

Malignant Peripheral Nerve Sheath Tumor With Perineurial Differentiation

Malignant Perineurioma

Perineurioma, Malignant

Frank-Ter Haar Syndrome

Ter Haar Syndrome	Borrone Dermatocardioskeletal Syndrome
FTHS	Autosomal Recessive Melnick-Needles Syndrome
Borrone Di Rocco Crovato Syndrome	Megalocornea, Multiple Skeletal Anomalies, And Developmental Delay
Melnick-Needles Syndrome, Autosomal Recessive, Formerly	Frank Ter Haar Syndrome

Otopalatodigital Syndrome Spectrum Disorder

Opd Spectrum Disorder	Opsd
Fronto-Otopalatodigital Osteodysplasia

Mandibular Cancer

Mandibular Neoplasms	Malignant Neoplasm Of Inferior Maxilla
Malignant Neoplasm Of Lower Jaw Bone	Malignant Neoplasm Of Mandible
Mandible Cancer	Mandibular Neoplasm
Neoplasm Of Mandible

Neurilemmomatosis

Schwannomatosis	Neurofibromatosis Type 3
Nf3	Neurilemmomatosis Congenital Cutaneous
Neurinomatosis	Congenital Cutaneous Neurilemmomatosis
Multiple Neurilemmomas	Multiple Schwannomas
Neurilemmomatosis, Congenital Cutaneous	Schwannomatosis 1
Neurofibromatosis 3	Mixed Central And Peripheral Neurofibromatosis
Nf3 - [Neurofibromatosis Type 3]

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12842	SH3PXD2A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SH3PXD2A	VGNC	VGNC:77297
Felis catus	SH3PXD2A	VGNC	VGNC:65112
Bos taurus	SH3PXD2A	VGNC	VGNC:55967
Mus musculus	SH3PXD2A	MGD	MGI:1298393
Canis familiaris	SH3PXD2A	VGNC	VGNC:46130
Rattus norvegicus	SH3PXD2A	RGD	RGD:1311185
Others	SH3PXD2A	NCBI

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