KNTC1 - kinetochore associated 1 Gene

Also Known as ROD

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9735

About KNTC1

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:122,527,249-122,626,396 (from NCBI)

This gene has 15 transcripts (splice variants) and 194 orthologues. Broad expression in testis (RPKM 11.5), bone marrow (RPKM 8.4) and 22 other tissues.

Summary

This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. Experimental evidence indicated that the encoded protein functioned in a similar manner to that of the Drosophila rough deal protein. [provided by RefSeq, Jul 2008]

KNTC1 Products (1)

mRNA Protein Name
NM_014708.6 NP_055523.1 kinetochore-associated protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11146660 GOA
Biological Process GO Annotation Evidence References Source
involved in mitotic spindle assembly checkpoint signaling IDA
IDA: Inferred from direct assay
11146660 GOA
Cellular Component GO Annotation Evidence References Source
part of RZZ complex IDA
IDA: Inferred from direct assay
20462495 GOA
part of RZZ complex IPI
IPI: Inferred from physical interaction
25849506 GOA
located in kinetochore microtubule IDA
IDA: Inferred from direct assay
11146660 GOA
located in spindle pole IDA
IDA: Inferred from direct assay
11146660 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KNTC1 Protein Structure

Rod_C

Rod_C: Rough deal protein C-terminal region (1580 - 2130)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2209 a.a.
Protein Preferred Names Protein Names

kinetochore-associated protein 1

  • Rough Deal homolog, centromere/kinetochore protein

KNTC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KNTC1 P50748 ZWILCH Homo sapiens Q9H900
GMS
20462495
Intra
KNTC1 P50748 ZWILCH Homo sapiens Q9H900
Pull Down
20462495
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07414 KNTC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris KNTC1 VGNC VGNC:42499
Mus musculus KNTC1 MGD MGI:2673709
Macaca mulatta KNTC1 VGNC VGNC:74064
Felis catus KNTC1 VGNC VGNC:63165
Bos taurus KNTC1 VGNC VGNC:30699
Rattus norvegicus KNTC1 RGD RGD:1307905
Others KNTC1 NCBI