LCMT2 - leucine carboxyl methyltransferase 2 Gene

Also Known as PPM2; TYW4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9836

About LCMT2

Cytogenetic location: 15q15.3 Genomic coordinates (GRCh38): 15:43,323,649-43,330,573 (from NCBI)

This gene has 2 transcripts (splice variants), 152 orthologues and 1 paralogue.

Summary

The protein encoded by this intronless gene belongs to the highly variable methyltransferase superfamily. This gene is the inferred homolog of the Saccharomyces cerevisiae carboxymethyltransferase gene PPM2 that is essential for the synthesis of the hypermodified guanosine Wybutosine (yW). [provided by RefSeq, Jul 2008]

LCMT2 Products (1)

mRNA Protein Name
NM_014793.5 NP_055608.2 tRNA wybutosine-synthesizing protein 4

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25910212 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LCMT2 Protein Structure

LCM

LCM: Leucine carboxyl methyltransferase (23 - 206)

Kelch_6

Kelch_6: Kelch motif (533 - 586)

  • 0
  • 200
  • 400
  • 600
  • 686 a.a.
Protein Preferred Names Protein Names

tRNA wybutosine-synthesizing protein 4

  • p21WAF1/CIP1 promoter-interacting protein

Related Diseases

Diseases Alias
Cerebral Creatine Deficiency Syndrome 3

  • Arginine:Glycine Amidinotransferase Deficiency

  • Agat Deficiency

  • Gatm Deficiency

  • Creatine Deficiency Syndrome Due To Agat Deficiency

  • L-Arginine:Glycine Amidinotransferase Deficiency

  • CCDS3

  • L-Arginine:Glycine Aminidotransferase Deficiency

  • Deficiency, Cerebral Creatine, Syndrome, Type 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07553 LCMT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LCMT2 VGNC VGNC:42610
Macaca mulatta LCMT2 VGNC VGNC:108312
Rattus norvegicus LCMT2 RGD RGD:1305829
Mus musculus LCMT2 MGD MGI:1353659
Bos taurus LCMT2 VGNC VGNC:30813