Lbr - lamin B receptor Gene

Also Known as ic; C14SR

Species: Mus musculus

Gene Type: protein coding
Gene ID: 98386

Summary

Enables delta14-sterol reductase activity. Involved in Cholesterol biosynthetic process and neutrophil differentiation. Located in nuclear membrane. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; liver; and lung. Used to study Pelger-Huet anomaly; ichthyosis vulgaris; and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Greenberg dysplasia; Pelger-Huet anomaly; and primary biliary cholangitis. Orthologous to human LBR (lamin B receptor). [provided by Alliance of Genome Resources, Apr 2022]

Lbr Products (1)

mRNA Protein Name
NM_133815.2 NP_598576.2 delta(14)-sterol reductase LBR

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin-protein adaptor activity IMP
IMP: Inferred from mutant phenotype
27492478 MGI
enables delta14-sterol reductase activity IMP
IMP: Inferred from mutant phenotype
18785926 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
26009488 MGI
Biological Process GO Annotation Evidence References Source
involved in cholesterol biosynthetic process IDA
IDA: Inferred from direct assay
18785926 MGI
involved in cholesterol biosynthetic process IMP
IMP: Inferred from mutant phenotype
22140257 MGI
involved in neutrophil differentiation IMP
IMP: Inferred from mutant phenotype
22140257 MGI
involved in random inactivation of X chromosome IMP
IMP: Inferred from mutant phenotype
25915022 MGI
Cellular Component GO Annotation Evidence References Source
located in nuclear envelope IDA
IDA: Inferred from direct assay
20457914 MGI
is active in nuclear lamina IDA
IDA: Inferred from direct assay
27492478 MGI
located in nuclear membrane IDA
IDA: Inferred from direct assay
18785926 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

delta(14)-sterol reductase LBR

  • 3-beta-hydroxysterol Delta (14)-reductase

  • C-14 sterol reductase

  • delta-14-SR

  • ichthyosis

  • integral nuclear envelope inner membrane protein

  • sterol C14-reductase

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99019 Fremanezumab Inhibitor 95.00% Unkown

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07545 LBR Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lbr NCBI NCBI:3930