2. Gene
  3. Lbr - lamin B receptor Gene

Lbr - lamin B receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ic; C14SR

Gene ID: 98386 | Gene type: protein coding

About Lbr

Summary

Enables delta14-sterol reductase activity. Involved in Cholesterol biosynthetic process and neutrophil differentiation. Located in nuclear membrane. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; liver; and lung. Used to study Pelger-Huet anomaly; ichthyosis vulgaris; and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Greenberg dysplasia; Pelger-Huet anomaly; and primary biliary cholangitis. Orthologous to human LBR (lamin B receptor). [provided by Alliance of Genome Resources, Apr 2022]

Lbr Products(1)

mRNA Protein Name
NM_133815.2 NP_598576.2 delta(14)-sterol reductase LBR
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chromatin-protein adaptor activity IMP
IMP: Inferred from mutant phenotype
27492478 MGI
enables delta14-sterol reductase activity IMP
IMP: Inferred from mutant phenotype
18785926 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
26009488 MGI
Biological Process GO Annotation Evidence Reference Source
involved in cholesterol biosynthetic process IDA
IDA: Inferred from direct assay
18785926 MGI
involved in cholesterol biosynthetic process IMP
IMP: Inferred from mutant phenotype
22140257 MGI
involved in neutrophil differentiation IMP
IMP: Inferred from mutant phenotype
22140257 MGI
involved in random inactivation of X chromosome IMP
IMP: Inferred from mutant phenotype
25915022 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nuclear envelope IDA
IDA: Inferred from direct assay
20457914 MGI
is active in nuclear lamina IDA
IDA: Inferred from direct assay
27492478 MGI
located in nuclear membrane IDA
IDA: Inferred from direct assay
18785926 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

delta(14)-sterol reductase LBR

3-beta-hydroxysterol Delta (14)-reductase

C-14 sterol reductase

delta-14-SR

ichthyosis

integral nuclear envelope inner membrane protein

sterol C14-reductase

Related Agents

Approval
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99019 Fremanezumab Inhibitor 95.00% Unkown
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07545 LBR Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lbr NCBI NCBI:3930