Atp1a2 - ATPase, Na+/K+ transporting, alpha 2 polypeptide Gene

Also Known as Atpa-3; mKIAA0778

Species: Mus musculus

Gene Type: protein coding
Gene ID: 98660

Summary

Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and alkali metal ion binding activity. Involved in several processes, including cellular response to steroid hormone stimulus; locomotory exploration behavior; and response to auditory stimulus. Acts upstream of or within several processes, including forebrain development; regulation of blood circulation; and regulation of muscle contraction. Located in T-tubule; cell projection; and neuronal cell body. Is expressed in several structures, including genitourinary system; heart; musculature; nervous system; and sensory organ. Used to study familial hemiplegic migraine 2. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; benign neonatal seizures; familial hemiplegic migraine 2; hypertension; and migraine with aura. Orthologous to human ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]

Atp1a2 Products (1)

mRNA Protein Name
NM_178405.3 NP_848492.1 sodium/potassium-transporting ATPase subunit alpha-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15485817 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within L-ascorbic acid metabolic process IGI
IGI: Inferred from genetic interaction
33544780 MGI
acts upstream of or within adult locomotory behavior IMP
IMP: Inferred from mutant phenotype
17234593 MGI
acts upstream of or within amygdala development IMP
IMP: Inferred from mutant phenotype
12805306 MGI
acts upstream of or within behavioral fear response IMP
IMP: Inferred from mutant phenotype
12805306 MGI
acts upstream of or within blood circulation IGI
IGI: Inferred from genetic interaction
33544780 MGI
involved in cellular response to steroid hormone stimulus IDA
IDA: Inferred from direct assay
16243970 MGI
acts upstream of or within fear response IMP
IMP: Inferred from mutant phenotype
21731499 MGI
acts upstream of or within locomotion IMP
IMP: Inferred from mutant phenotype
12458206 MGI
involved in locomotory exploration behavior IMP
IMP: Inferred from mutant phenotype
20936682 MGI
acts upstream of or within membrane depolarization IMP
IMP: Inferred from mutant phenotype
30819023 MGI
acts upstream of or within negative regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
10360172 MGI
acts upstream of or within negative regulation of heart contraction IMP
IMP: Inferred from mutant phenotype
10360172 MGI
acts upstream of or within negative regulation of striated muscle contraction IMP
IMP: Inferred from mutant phenotype
11507009 MGI
acts upstream of or within neuronal action potential propagation IMP
IMP: Inferred from mutant phenotype
21731499 MGI
acts upstream of or within neurotransmitter uptake IMP
IMP: Inferred from mutant phenotype
12805306 MGI
involved in neurotransmitter uptake IMP
IMP: Inferred from mutant phenotype
12805306 MGI
acts upstream of or within olfactory cortex development IMP
IMP: Inferred from mutant phenotype
12805306 MGI
acts upstream of or within regulation of blood pressure IGI
IGI: Inferred from genetic interaction
16243970 MGI
acts upstream of or within regulation of muscle contraction IMP
IMP: Inferred from mutant phenotype
10360172 MGI
acts upstream of or within regulation of respiratory gaseous exchange by nervous system process IMP
IMP: Inferred from mutant phenotype
12458206 MGI
acts upstream of or within regulation of smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
14627611 MGI
acts upstream of or within regulation of striated muscle contraction IMP
IMP: Inferred from mutant phenotype
15253893 MGI
acts upstream of or within regulation of the force of heart contraction IMP
IMP: Inferred from mutant phenotype
10360172 MGI
acts upstream of or within regulation of vasoconstriction IGI
IGI: Inferred from genetic interaction
14627611 MGI
acts upstream of or within regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
14627611 MGI
involved in response to auditory stimulus IMP
IMP: Inferred from mutant phenotype
20936682 MGI
involved in response to glycoside IMP
IMP: Inferred from mutant phenotype
16243970 MGI
acts upstream of or within response to potassium ion IMP
IMP: Inferred from mutant phenotype
30819023 MGI
acts upstream of or within visual learning IMP
IMP: Inferred from mutant phenotype
17234593 MGI
Cellular Component GO Annotation Evidence References Source
located in T-tubule IDA
IDA: Inferred from direct assay
16292983 MGI
located in cell projection IDA
IDA: Inferred from direct assay
12458206 MGI
is active in cell surface IDA
IDA: Inferred from direct assay
17804407 MGI
is active in endoplasmic reticulum IDA
IDA: Inferred from direct assay
21731499 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
12458206 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
21731499 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
17804407 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
15485817 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium/potassium-transporting ATPase subunit alpha-2

  • Na(+)/K(+) ATPase alpha(+) subunit

  • Na(+)/K(+) ATPase alpha-2 subunit

  • sodium pump subunit alpha-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01183 ATP1A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01187 ATP1B2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21822 Atp1a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21823 Atp1b2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28339 Atp1a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp1a2 NCBI NCBI:477