HAGH - hydroxyacylglutathione hydrolase Gene

Also Known as GLO2; GLX2; GLXII; HAGH1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3029

About HAGH

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,807,629-1,827,194 (from NCBI)

This gene has 12 transcripts (splice variants), 202 orthologues, 4 paralogues and is associated with 1 phenotype. Broad expression in kidney (RPKM 47.0), liver (RPKM 45.0) and 25 other tissues.

Summary

The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

HAGH Products (5)

mRNA Protein Name
NM_001040427.2 NP_001035517.1 hydroxyacylglutathione hydrolase, mitochondrial isoform 2
NM_001286249.2 NP_001273178.1 hydroxyacylglutathione hydrolase, mitochondrial isoform 3 precursor
NM_001363912.1 NP_001350841.1 hydroxyacylglutathione hydrolase, mitochondrial isoform 4 precursor
NM_001363914.1 NP_001350843.1 hydroxyacylglutathione hydrolase, mitochondrial isoform 5
NM_005326.6 NP_005317.2 hydroxyacylglutathione hydrolase, mitochondrial isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hydroxyacylglutathione hydrolase activity IDA
IDA: Inferred from direct assay
8550579 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
Biological Process GO Annotation Evidence References Source
involved in glutathione biosynthetic process IDA
IDA: Inferred from direct assay
8550579 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15117945 GOA
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
15117945 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HAGH Protein Structure

Lactamase_B

Lactamase_B: Metallo-beta-lactamase superfamily (57 - 221)

  • 0
  • 100
  • 200
  • 308 a.a.
Protein Preferred Names Protein Names

hydroxyacylglutathione hydrolase, mitochondrial

  • glyoxalase II

HAGH Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HAGH Q16775 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Intra
HAGH Q16775 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HAGH Proteins

Cat. No. Product Name Accession Purity
HY-P71690 GLO2/Glyoxalase II Protein, Human (GST) Q16775-1 (K50-D308) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Hydroxyacyl Glutathione Hydrolase Deficiency

  • Glyoxalase Ii Deficiency
Triosephosphate Isomerase Deficiency

  • TPID

  • Triose Phosphate-Isomerase Deficiency

  • Hemolytic Anemia Due To Triosephosphate Isomerase Deficiency

  • Tpi Deficiency

  • Triose Phosphate Isomerase Deficiency

  • Deficiency Of Phosphotriose Isomerase

  • Hereditary Nonspherocytic Hemolytic Anemia Due To Triosephosphate Isomerase Deficiency
Yaws

  • Frambesia

  • Frambesia Tropica

  • Bouba

  • Frambosie

  • Polypapilloma Tropicum

  • Thymosis

  • Endemic Treponematoses

  • Treponema Pertenue Infection

  • Pian

  • Framboesia

  • Framboesia Tropica

  • Castellani

  • Infection By Treponema Pertenue

  • Parangi

  • Framboesioma

  • Chancre Of Yaws

  • Primary Framboesia

  • Initial Lesions Of Yaws

  • Mother Yaw

  • Initial Framboesia
Encephalopathy, Ethylmalonic

  • Ethylmalonic Encephalopathy

  • EE

  • Epema Syndrome

  • Encephalopathy, Petechiae, And Ethylmalonic Aciduria

  • Ethe1 Deficiency

  • Eme

  • Syndrome Of Encephalopathy, Petechiae, And Ethylmalonic Aciduria
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05992 HAGH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20285 Hagh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26793 Hagh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HAGH VGNC VGNC:41585
Mus musculus HAGH MGD MGI:95745
Bos taurus HAGH VGNC VGNC:29742
Felis catus HAGH VGNC VGNC:67533
Rattus norvegicus HAGH RGD RGD:2779
Macaca mulatta HAGH VGNC VGNC:73343
Others HAGH NCBI