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Cat. No.: HY-169008

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PROTAC ACC degrader-1

PROTAC ACC degrader-1 is an Acetyl-CoA Carboxylase PROTAC degrader with insecticidal activity, which induces ACC protein degradation via the ubiquitin-proteasome system. PROTAC ACC degrader-1 exhibits significant dose-dependent insecticidal activity against Aphis craccivora nymphs. PROTAC ACC degrader-1 can be used in studies related to Aphis craccivora infestation.
(Pink: Acetyl-CoA Carboxylase ligand (HY-169009); Blue: Cereblon ligand (HY-10984); Black: linker (HY-W007559)).

For research use only. We do not sell to patients.

Formula: C₃₇H₄₂N₄O₈
Molecular Weight:670.75

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (285 KB)

PROTAC ACC degrader-1 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PROTAC ACC degrader-1 is an Acetyl-CoA Carboxylase PROTAC degrader with insecticidal activity, which induces ACC protein degradation via the ubiquitin-proteasome system. PROTAC ACC degrader-1 exhibits significant dose-dependent insecticidal activity against Aphis craccivora nymphs. PROTAC ACC degrader-1 can be used in studies related to Aphis craccivora infestation^[1]. (Pink: Acetyl-CoA Carboxylase ligand (HY-169009); Blue: Cereblon ligand (HY-10984); Black: linker (HY-W007559)).

All PROTACs Isoforms :

In Vitro

PROTAC ACC degrader-1 (compound 9b) (0.39-100 μM; 48 h) efficiently degrades ACC protein in Sf9 cells through the ubiquitin-proteasome system^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Sf9 cells
Concentration:

0.39, 1.56, 6.25, 25, 50, 100 μM (48 h incubation)
25 μM (48 h incubation with pre-treatment of Pomalidomide (HY-10984) 25 μM, MG-132 (HY-13259) 10 μM, or Spirotetramat-enol (HY-W587734) 25 μM)
Incubation Time:

48 h (main treatment)
12 h (Pomalidomide pre-treatment)
6 h (MG-132 pre-treatment)
8 h (Spirotetramat-enolpre-treatment)
Result:

Exhibited concentration-dependent ACC degradation in Sf9 cells, with a "hook effect" observed at higher concentrations.
Almost completely degraded ACC protein at concentrations of 1.56, 6.25, and 25 μM.
Showed significantly reduced ACC protein degradation when cells were pretreated with pomalidomide, MG-132, or spirotetramat enol.

In Vivo

PROTAC ACC degrader-1 (compound 9b) (62.5-500 μg/mL; topical application via leaf dipping; single exposure) exhibits significant dose-dependent insecticidal activity against Aphis craccivora nymphs, with an LC₅₀ of 107.8 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

bean aphid nymphs^[1]
Dosage:

62.5, 91.3, 125, 182.5, 250, 500 μg/mL
Administration:

topical application via leaf dipping; single exposure
Result:

Attained 100%, 81.6%, 72.5%, 53.8%, 44.6% and 27.7% mortality of nymph aphids at 500 μg/mL, 250 μg/mL, 182.5 μg/mL, 125 μg/mL, 91.3 μg/mL and 62.5 μg/mL respectively, and determined the LC₅₀ value to be 107.8 μg/mL.

Chemical Information

Molecular Weight 670.75
Formula C₃₇H₄₂N₄O₈
SMILES

CC1=C(C2=C(OCCCCCC(NC3=C(C(N(C4C(NC(CC4)=O)=O)C5=O)=O)C5=CC=C3)=O)C6(CCC(OC)CC6)NC2=O)C=C(C)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (285 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xu Q, et al. Acetyl-CoA Carboxylase Proteolysis-Targeting Chimeras: Conceptual Design and Application as Insecticides. Journal of agricultural and food chemistry. 2024 Aug 28;72(34):18809-18815. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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PROTAC ACC degrader-1

All PROTACs Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC ACC degrader-1 Related Classifications

HY-169008 Related Classifications