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Cat. No.: HY-187357

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PROTAC KAT6 Degrader-2

PROTAC KAT6 Degrader-2 is a KAT6A PROTAC degrader. PROTAC KAT6 Degrader-2 induces ubiquitination and proteasomal degradation of KAT6A. PROTAC KAT6 Degrader-2 exhibits high maximum fold activity in ternary complex formation assays. PROTAC KAT6 Degrader-2 can be used in studies related to breast cancer.

For research use only. We do not sell to patients.

Formula: C₄₂H₄₇N₉O₁₀S
Molecular Weight:869.94

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC KAT6 Degrader-2 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All PROTACs Isoforms :

All Histone Acetyltransferase Isoforms :

In Vitro

PROTAC KAT6 Degrader-2 (Compound 14) exhibits superior antiproliferative activity in breast cancer cells relative to conventional orthosteric KAT6 inhibitors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 869.94
Formula C₄₂H₄₇N₉O₁₀S
SMILES

COC1=NC(C(NS(=O)(C2=C(OC)C(N3CCN(CC4CCN(C5=CC(C(N(C6CCC(NC6=O)=O)C7=O)=O)=C7C=C5)CC4)CC3)=CC=C2OC)=O)=O)=CC=C1CN8C=CC=N8
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Renner, A. C., & Kargbo, R. B. (2026). Targeted Degradation of KAT6A: Expanding the Therapeutic Frontier of Epigenetic Drug Discovery. ACS Medicinal Chemistry Letters.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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PROTAC KAT6 Degrader-2

All PROTACs Isoforms

All Histone Acetyltransferase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC KAT6 Degrader-2 Related Classifications

HY-187357 Related Classifications