STING agonist-22
Based on 2 publication(s) in Google Scholar
STING agonist-22 (CF501) is a potent non-nucleotide STING agonist. STING agonist-22 is a adjuvant by activating STING to induce the type I interferon (IFN-I) response and proinflammatory cytokine production. STING agonist-22 can be used as an adjuvant to boost the original protein vaccine, producing potent, broad, and long-term immune protection. STING agonist-22 can be used for SARS-CoV-2 variants and sarbecovirus diseases research.
For research use only. We do not sell to patients.
- Purity: 99.83%
- CAS No.: 2408723-12-4
- Formula: C40H48N14O6
- Molecular Weight:820.90
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) STING agonist-22
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c mice (female, six weeks old)[1]
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Dosage:20, 75 μg
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Administration:Intramuscular injection
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Result:Although innate immunity was activated only transiently by CF501, it should be sufficient to stimulate the required humoral and cellular immune responses. The half-life of CF501 was 0.5 h and there was no detectable CF501 in the plasma after 2 h of the injection.
Chemical Information
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CAS No. 2408723-12-4
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Appearance Solid
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Molecular Weight 820.90
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Formula C40H48N14O6
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Color White to off-white
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SMILES
NC(C1=CC2=C(N=C1)N(C/C=C/CN3C(NC(C4=CC(C)=NN4CC)=O)=NC5=C3C(OCCCN6CCOCC6)=CC(C(N)=O)=C5)C(NC(C7=CC(C)=NN7CC)=O)=N2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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NPJ Vaccines
Universal broad-spectrum mucosal vaccine design for human coronaviruses inspired by artificial antibodies. [Abstract]2026 Jan 28;11(1):55. PMID: 41605953 -
Solvent & Solubility
DMSO : 100 mg/mL (121.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2182 mL | 6.0909 mL | 12.1818 mL | 30.4544 mL |
| 5 mM | 0.2436 mL | 1.2182 mL | 2.4364 mL | 6.0909 mL | |
| 10 mM | 0.1218 mL | 0.6091 mL | 1.2182 mL | 3.0454 mL | |
| 15 mM | 0.0812 mL | 0.4061 mL | 0.8121 mL | 2.0303 mL | |
| 20 mM | 0.0609 mL | 0.3045 mL | 0.6091 mL | 1.5227 mL | |
| 25 mM | 0.0487 mL | 0.2436 mL | 0.4873 mL | 1.2182 mL | |
| 30 mM | 0.0406 mL | 0.2030 mL | 0.4061 mL | 1.0151 mL | |
| 40 mM | 0.0305 mL | 0.1523 mL | 0.3045 mL | 0.7614 mL | |
| 50 mM | 0.0244 mL | 0.1218 mL | 0.2436 mL | 0.6091 mL | |
| 60 mM | 0.0203 mL | 0.1015 mL | 0.2030 mL | 0.5076 mL | |
| 80 mM | 0.0152 mL | 0.0761 mL | 0.1523 mL | 0.3807 mL | |
| 100 mM | 0.0122 mL | 0.0609 mL | 0.1218 mL | 0.3045 mL |
STING agonist-22 Related Classifications
HY-152955 Related Classifications
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