DR1 - down-regulator of transcription 1 Gene

Also Known as NC2; NC2B; NCB2; NC2-BETA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1810

About DR1

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:93,345,907-93,369,493 (from NCBI)

This gene has 3 transcripts (splice variants), 214 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 31.0), lymph node (RPKM 21.9) and 25 other tissues.

Summary

This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008]

DR1 Products (1)

mRNA Protein Name
NM_001938.3 NP_001929.1 protein Dr1
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II general transcription initiation factor activity IDA
IDA: Inferred from direct assay
8670811 GOA
enables TBP-class protein binding IDA
IDA: Inferred from direct assay
18838386 GOA
enables TBP-class protein binding IPI
IPI: Inferred from physical interaction
8670811 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
8670811 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8670811 GOA
involved in regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19936620 GOA
involved in regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
19103755 GOA
involved in regulation of cell division IDA
IDA: Inferred from direct assay
20562830 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
22055187 GOA
involved in regulation of tubulin deacetylation IMP
IMP: Inferred from mutant phenotype
20562830 GOA
Cellular Component GO Annotation Evidence References Source
part of ATAC complex IDA
IDA: Inferred from direct assay
18838386 GOA
part of RNA polymerase II transcription regulator complex IDA
IDA: Inferred from direct assay
8670811 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DR1 Protein Structure

CBFD_NFYB_HMF

CBFD_NFYB_HMF: Histone-like transcription factor (CBF/NF-Y) and archaeal histone (12 - 75)

  • 0
  • 100
  • 176 a.a.
Protein Preferred Names Protein Names

protein Dr1

  • TATA-binding protein-associated phosphoprotein

DR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DR1 Q01658 ZSCAN22 Homo sapiens P10073 32814053
Intra
DR1 Q01658 ZSCAN22 Homo sapiens P10073 32814053
Intra
DR1 Q01658 ZSCAN22 Homo sapiens P10073 32814053
Intra
DR1 Q01658 TBP Homo sapiens Q32MN6 32296183
Intra
DR1 Q01658 ASCL4 Homo sapiens Q6XD76 32814053
Intra
DR1 Q01658 ASCL4 Homo sapiens Q6XD76 32814053
Intra
DR1 Q01658 ASCL4 Homo sapiens Q6XD76 32814053
Intra
DR1 Q01658 JADE3 Homo sapiens Q92613 32814053
Intra
DR1 Q01658 JADE3 Homo sapiens Q92613 32814053
Intra
DR1 Q01658 JADE3 Homo sapiens Q92613 32814053
Intra
DR1 Q01658 PBX4 Homo sapiens Q9BYU1 32814053
Intra
DR1 Q01658 PBX4 Homo sapiens Q9BYU1 32814053
Intra
DR1 Q01658 PBX4 Homo sapiens Q9BYU1 32814053
Intra
DR1 Q01658 q9h669_human Homo sapiens Q9H669 32814053
Intra
DR1 Q01658 q9h669_human Homo sapiens Q9H669 32814053
Intra
DR1 Q01658 q9h669_human Homo sapiens Q9H669 32814053
Intra
DR1 Q01658 LARP4B Homo sapiens Q92615 32814053
Intra
DR1 Q01658 LARP4B Homo sapiens Q92615 32814053
Intra
DR1 Q01658 LARP4B Homo sapiens Q92615 32814053
Intra
DR1 Q01658 MAGEC3 Homo sapiens Q8TD91-2 32814053
Intra
DR1 Q01658 MAGEC3 Homo sapiens Q8TD91-2 32814053
Intra
DR1 Q01658 MAGEC3 Homo sapiens Q8TD91-2 32814053
Intra
DR1 Q01658 USP2 Homo sapiens O75604-3 32814053
Intra
DR1 Q01658 USP2 Homo sapiens O75604-3 32814053
Intra
DR1 Q01658 USP2 Homo sapiens O75604-3 32814053
Intra
DR1 Q01658 C14orf93 Homo sapiens Q9H972-2 32814053
Intra
DR1 Q01658 C14orf93 Homo sapiens Q9H972-2 32814053
Intra
DR1 Q01658 C14orf93 Homo sapiens Q9H972-2 32814053
Intra
DR1 Q01658 EMILIN1 Homo sapiens Q9Y6C2-2 32814053
Intra
DR1 Q01658 EMILIN1 Homo sapiens Q9Y6C2-2 32814053
Intra
DR1 Q01658 EMILIN1 Homo sapiens Q9Y6C2-2 32814053
Intra
DR1 Q01658 CFAP100 Homo sapiens Q494V2-2 32814053
Intra
DR1 Q01658 CFAP100 Homo sapiens Q494V2-2 32814053
Intra
DR1 Q01658 CFAP100 Homo sapiens Q494V2-2 32814053
Intra
DR1 Q01658 NFYC Homo sapiens Q13952-2 32296183
Intra
DR1 Q01658 ZC2HC1C Homo sapiens Q53FD0-2 32814053
Intra
DR1 Q01658 ZC2HC1C Homo sapiens Q53FD0-2 32814053
Intra
DR1 Q01658 ZC2HC1C Homo sapiens Q53FD0-2 32814053
Intra
DR1 Q01658 PRMT1 Homo sapiens Q99873-2 32814053
Intra
DR1 Q01658 PRMT1 Homo sapiens Q99873-2 32814053
Intra
DR1 Q01658 PRMT1 Homo sapiens Q99873-2 32814053
Intra
DR1 Q01658 ZNF829 Homo sapiens Q3KNS6-3 32814053
Intra
DR1 Q01658 ZNF829 Homo sapiens Q3KNS6-3 32814053
Intra
DR1 Q01658 ZNF829 Homo sapiens Q3KNS6-3 32814053
Intra
DR1 Q01658 NVL Homo sapiens O15381-5 32814053
Intra
DR1 Q01658 NVL Homo sapiens O15381-5 32814053
Intra
DR1 Q01658 NVL Homo sapiens O15381-5 32814053
Intra
DR1 Q01658 DPP9 Homo sapiens Q86TI2-2 32814053
Intra
DR1 Q01658 DPP9 Homo sapiens Q86TI2-2 32814053
Intra
DR1 Q01658 DPP9 Homo sapiens Q86TI2-2 32814053
Intra
DR1 Q01658 GOLGA2P5 Homo sapiens Q9HBQ8 32814053
Intra
DR1 Q01658 GOLGA2P5 Homo sapiens Q9HBQ8 32814053
Intra
DR1 Q01658 GOLGA2P5 Homo sapiens Q9HBQ8 32814053
Intra
DR1 Q01658 PHF19 Homo sapiens Q5T6S3 32814053
Intra
DR1 Q01658 PHF19 Homo sapiens Q5T6S3 32814053
Intra
DR1 Q01658 PHF19 Homo sapiens Q5T6S3 32814053
Intra
DR1 Q01658 RNF34 Homo sapiens Q969K3 32814053
Intra
DR1 Q01658 RNF34 Homo sapiens Q969K3 32814053
Intra
DR1 Q01658 RNF34 Homo sapiens Q969K3 32814053
Intra
DR1 Q01658 DPF1 Homo sapiens Q92782-2 32814053
Intra
DR1 Q01658 DPF1 Homo sapiens Q92782-2 32814053
Intra
DR1 Q01658 DPF1 Homo sapiens Q92782-2 32814053
Intra
DR1 Q01658 ANXA8 Homo sapiens P13928 32814053
Intra
DR1 Q01658 ANXA8 Homo sapiens P13928 32814053
Intra
DR1 Q01658 ANXA8 Homo sapiens P13928 32814053
Intra
DR1 Q01658 ZNF488 Homo sapiens Q96MN9-2 32814053
Intra
DR1 Q01658 ZNF488 Homo sapiens Q96MN9-2 32814053
Intra
DR1 Q01658 ZNF488 Homo sapiens Q96MN9-2 32814053
Intra
DR1 Q01658 HES4 Homo sapiens Q9HCC6 32814053
Intra
DR1 Q01658 HES4 Homo sapiens Q9HCC6 32814053
Intra
DR1 Q01658 HES4 Homo sapiens Q9HCC6 32814053
Intra
DR1 Q01658 KLF15 Homo sapiens Q9UIH9 32814053
Intra
DR1 Q01658 KLF15 Homo sapiens Q9UIH9 32814053
Intra
DR1 Q01658 KLF15 Homo sapiens Q9UIH9 32814053
Intra
DR1 Q01658 GPSM3 Homo sapiens Q9Y4H4 32814053
Intra
DR1 Q01658 GPSM3 Homo sapiens Q9Y4H4 32814053
Intra
DR1 Q01658 GPSM3 Homo sapiens Q9Y4H4 32814053
Intra
DR1 Q01658 RPS4X Homo sapiens P62701 32814053
Intra
DR1 Q01658 RPS4X Homo sapiens P62701 32814053
Intra
DR1 Q01658 RPS4X Homo sapiens P62701 32814053
Intra
DR1 Q01658 RPP25 Homo sapiens Q9BUL9 32814053
Intra
DR1 Q01658 RPP25 Homo sapiens Q9BUL9 32814053
Intra
DR1 Q01658 RPP25 Homo sapiens Q9BUL9 32814053
Intra
DR1 Q01658 FAM117B Homo sapiens Q6P1L5 32814053
Intra
DR1 Q01658 FAM117B Homo sapiens Q6P1L5 32814053
Intra
DR1 Q01658 FAM117B Homo sapiens Q6P1L5 32814053
Intra
DR1 Q01658 MYC Homo sapiens P01106 32814053
Intra
DR1 Q01658 MYC Homo sapiens P01106 32814053
Intra
DR1 Q01658 MYC Homo sapiens P01106 32814053
Intra
DR1 Q01658 LPIN1 Homo sapiens Q14693 32814053
Intra
DR1 Q01658 LPIN1 Homo sapiens Q14693 32814053
Intra
DR1 Q01658 LPIN1 Homo sapiens Q14693 32814053
Intra
DR1 Q01658 FAM98C Homo sapiens Q17RN3 32814053
Intra
DR1 Q01658 FAM98C Homo sapiens Q17RN3 32814053
Intra
DR1 Q01658 FAM98C Homo sapiens Q17RN3 32814053
Intra
DR1 Q01658 SAP30 Homo sapiens O75446 32814053
Intra
DR1 Q01658 SAP30 Homo sapiens O75446 32814053
Intra
DR1 Q01658 SAP30 Homo sapiens O75446 32814053
Intra
DR1 Q01658 VSX2 Homo sapiens P58304 32814053
Intra
DR1 Q01658 VSX2 Homo sapiens P58304 32814053
Intra
DR1 Q01658 VSX2 Homo sapiens P58304 32814053
Intra
DR1 Q01658 DRAP1 Homo sapiens Q14919
SLC
31467278
Intra
DR1 Q01658 DRAP1 Homo sapiens Q14919 29997244
Intra
DR1 Q01658 DRAP1 Homo sapiens Q14919 18692475
Intra
DR1 Q01658 DRAP1 Homo sapiens Q14919 29997244
Intra
DR1 Q01658 DRAP1 Homo sapiens Q14919 31467278
Intra
DR1 Q01658 STRN4 Homo sapiens Q9NRL3 32814053
Intra
DR1 Q01658 STRN4 Homo sapiens Q9NRL3 32814053
Intra
DR1 Q01658 STRN4 Homo sapiens Q9NRL3 32814053
Intra
DR1 Q01658 MPC2 Homo sapiens O95563 32814053
Intra
DR1 Q01658 MPC2 Homo sapiens O95563 32814053
Intra
DR1 Q01658 MPC2 Homo sapiens O95563 32814053
Intra
DR1 Q01658 RNF183 Homo sapiens Q96D59 32814053
Intra
DR1 Q01658 RNF183 Homo sapiens Q96D59 32814053
Intra
DR1 Q01658 RNF183 Homo sapiens Q96D59 32814053
Intra
DR1 Q01658 POLE3 Homo sapiens Q9NRF9 32296183
Intra
DR1 Q01658 POLE3 Homo sapiens Q9NRF9 16189514
Intra
DR1 Q01658 POLE3 Homo sapiens Q9NRF9 32296183
Intra
DR1 Q01658 ZNF581 Homo sapiens Q9P0T4 32814053
Intra
DR1 Q01658 ZNF581 Homo sapiens Q9P0T4 32814053
Intra
DR1 Q01658 ZNF581 Homo sapiens Q9P0T4 32814053
Intra
DR1 Q01658 RAI2 Homo sapiens Q9Y5P3 32814053
Intra
DR1 Q01658 RAI2 Homo sapiens Q9Y5P3 32814053
Intra
DR1 Q01658 RAI2 Homo sapiens Q9Y5P3 32814053
Intra
DR1 Q01658 TACO1 Homo sapiens Q9BSH4 32814053
Intra
DR1 Q01658 TACO1 Homo sapiens Q9BSH4 32814053
Intra
DR1 Q01658 TACO1 Homo sapiens Q9BSH4 32814053
Intra
DR1 Q01658 GMPPA Homo sapiens Q96IJ6 32814053
Intra
DR1 Q01658 GMPPA Homo sapiens Q96IJ6 32814053
Intra
DR1 Q01658 GMPPA Homo sapiens Q96IJ6 32814053
Intra
DR1 Q01658 SEM1 Homo sapiens P60896 32814053
Intra
DR1 Q01658 SEM1 Homo sapiens P60896 32814053
Intra
DR1 Q01658 SEM1 Homo sapiens P60896 32814053
Intra
DR1 Q01658 SPPL2B Homo sapiens Q8TCT7-2 32814053
Intra
DR1 Q01658 SPPL2B Homo sapiens Q8TCT7-2 32814053
Intra
DR1 Q01658 SPPL2B Homo sapiens Q8TCT7-2 32814053
Intra
DR1 Q01658 FAM9A Homo sapiens Q8IZU1 32814053
Intra
DR1 Q01658 FAM9A Homo sapiens Q8IZU1 32814053
Intra
DR1 Q01658 FAM9A Homo sapiens Q8IZU1 32814053
Intra
DR1 Q01658 TIMM44 Homo sapiens O43615 32814053
Intra
DR1 Q01658 TIMM44 Homo sapiens O43615 32814053
Intra
DR1 Q01658 TIMM44 Homo sapiens O43615 32814053
Intra
DR1 Q01658 CSNK1D Homo sapiens P48730-2 32814053
Intra
DR1 Q01658 CSNK1D Homo sapiens P48730-2 32814053
Intra
DR1 Q01658 CSNK1D Homo sapiens P48730-2 32814053
Intra
DR1 Q01658 LOC401296 Homo sapiens A2RU56 32814053
Intra
DR1 Q01658 LOC401296 Homo sapiens A2RU56 32814053
Intra
DR1 Q01658 LOC401296 Homo sapiens A2RU56 32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

DR1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89757 DR1 Antibody (YA9101) WB, ICC/IF, IF-Tissue, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Oesophagostomiasis
  • Infection By Oesophagostomum

  • Oesophagostomosis

Trichostrongylosis
  • Trichostrongyliasis

  • Infection By Trichostrongylus

  • Infection By Trichostrongylus Species

  • Trichostrongylus Infestation

Recessive Dystrophic Epidermolysis Bullosa
  • Autosomal Recessive Dystrophic Epidermolysis Bullosa Generalisata Gravis

  • Autosomal Recessive Dystrophic Epidermolysis Bullosa, Hallopeau-Siemens Type

  • Rdeb, Hallopeau-Siemens Type

  • Severe Generalized Rdeb

  • Severe Generalized Recessive Dystrophic Epidermolysis Bullosa

  • Rdeb Generalisata Gravis

  • Rdeb, Severe Generalized

  • Rdeb-Sev Gen

  • Recessive Dystrophic Epidermolysis Bullosa, Severe Generalized

  • Hallopeau-Siemens Disease

Epidermolysis Bullosa Dystrophica, Pretibial
  • Epidermolysis Bullosa, Pretibial

  • Pretibial Dystrophic Epidermolysis Bullosa

  • Deb-Pt

  • Dystrophic Epidermolysis Bullosa, Pretibial

  • Deb, Pretibial

  • Pretibial Epidermolysis Bullosa

  • Pretibial Deb

  • Localized Dystrophic Epidermolysis Bullosa, Pretibial Form

  • Localized Deb, Pretibial Form

  • Epidermolysis Bullosa Dystrophica, Pretibial Type

  • PR-DEB

Corneal Dystrophy, Subepithelial Mucinous
  • Subepithelial Mucinous Corneal Dystrophy

  • SMCD

Spondyloepimetaphyseal Dysplasia, Strudwick Type
  • Spondylometaphyseal Dysplasia

  • Strudwick Syndrome

  • Dappled Metaphysis Syndrome

  • Semd, Strudwick Type

  • Spondylometaepiphyseal Dysplasia Congenita, Strudwick Type

  • Smed, Strudwick Type

  • Smd

  • Smed Strudwick Type

  • SEMDSTWK

  • Smed, Type I

  • Semdc

  • Smed Type 1

  • Spondyloepimetaphyseal Dysplasia Strudwick Type

  • Sed Strudwick

  • Spondyloepimetaphyseal Dysplasia Congenita, Strudwick Type

  • Smed Type I

  • Spondyloepiphyseal Dysplasia Congenita With Dappled Metaphyses

  • Dysplasia, Spondyloepimetaphyseal, Strudwick Type

  • Dysplasia, Spondylometaphyseal

Trichostrongyloidiasis
Anisakiasis
  • Infection By Anisakis Larva

  • Anisakis Infection

  • Pseudoterranova Infection

  • Anisakiasis Due To Anisakis Simplex

  • Anisakiasis Due To Pseudoterranova Decipiens

  • Anisakis Infestation

  • Infection Due To Anisakis Larvae

Metaphyseal Chondrodysplasia, Schmid Type
  • MCDS

  • Schmid Metaphyseal Chondrodysplasia

  • Metaphyseal Chondrodysplasia Schmid Type

  • Spondylometaphyseal Dysplasia, Japanese Type

  • Japanese Type Spondylometaphyseal Dysplasia

  • Schmid Type Metaphyseal Dysplasia

  • Metaphyseal Chondrodysplasia Type Schmid

  • Schmid Type Metaphyseal Chondrodysplasia

  • SMCD

  • Chondrodysplasia, Metaphyseal, Schmid Type

  • Corneal Dystrophy, Subepithelial Mucinous

Ancylostomiasis
  • Ankylostomiasis

  • Hookworm Infection

  • Hookworm Infections

  • Ancylostomiasis Due To Ancylostoma Duodenale

  • Ancylostoma Duodenale Infection

Transient Bullous Dermolysis Of The Newborn
  • TBDN

  • Transient Bullous Of The Newborn

  • Epidermolysis Bullosa Dystrophica, Neonatal Form

  • Dystrophic Epidermolysis Bullosa, Neonatal

  • Deb, Bullous Dermolysis Of The Newborn

  • Deb-Bdn

  • Epidermolysis Bullosa Dystrophica, Dominant Neonatal Form

  • Self-Improving Dystrophic Epidermolysis Bullosa

  • Self-Improving Deb

  • Epidermolysis Bullosa Dystrophica Dominant Neonatal Type

Traumatic Glaucoma
  • Glaucoma Associated With Ocular Trauma

Epidermolysis Bullosa Dystrophica
  • Dystrophic Epidermolysis Bullosa

  • Deb

  • Dermolytic Epidermolysis Bullosa

  • Epidermolysis Bullosa, Dermolytic

  • Epidermolysis Bullosa, Dystrophic

  • Epidermolysis Bullosa Dystrophic

  • Dystrophic Eb - [Epidermolysis Bullosa]

Internal Hordeolum
Noonan Syndrome 2
  • NS2

  • Noonan Syndrome, Autosomal Recessive

  • Noonan Syndrome 2, Autosomal Recessive

  • Noonan Syndrome, Type 2

Hypoparathyroidism-Deafness-Renal Disease Syndrome
  • Barakat Syndrome

  • Hypoparathyroidism, Deafness, Renal Disease Syndrome

  • Hdr Syndrome

  • Hypoparathyroidism, Sensorineural Deafness, And Renal Disease

Acquired Color Blindness
  • Acquired Color Vision Deficiencies

  • Acquired Color Vision Deficiency

  • Acquired Colour Blindness

  • Acquired Colour Vision Deficiencies

  • Acquired Colour Vision Deficiency

Toxocariasis
  • Toxocara Infection

  • Visceral Larva Migrans

  • Larva Migrans, Visceral

  • Infection By Toxascaris

  • Larva Migrans Visceral

  • Larva Migrans Visceralis

  • Toxocaral Visceral Larva Migrans

  • Visceral Larva Migrans Syndrome

  • Toxocara Infestation

Bullous Skin Disease
  • Skin Diseases Bullous

  • Skin Diseases, Bullous

Epithelial And Subepithelial Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus DR1 VGNC VGNC:80190
Mus musculus DR1 MGD MGI:1100515
Bos taurus DR1 VGNC VGNC:28200
Rattus norvegicus DR1 RGD RGD:1305201
Canis familiaris DR1 VGNC VGNC:40087
Others DR1 NCBI