DR1 - down-regulator of transcription 1 Gene
Also Known as NC2; NC2B; NCB2; NC2-BETA
Species: Homo sapiens
About DR1
This gene has 3 transcripts (splice variants), 214 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 31.0), lymph node (RPKM 21.9) and 25 other tissues.
Summary
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008]
DR1 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_001938.3 | NP_001929.1 | protein Dr1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables RNA polymerase II general transcription initiation factor activity |
IDA
IDA: Inferred from direct assay
|
8670811 | GOA |
| enables TBP-class protein binding |
IDA
IDA: Inferred from direct assay
|
18838386 | GOA |
| enables TBP-class protein binding |
IPI
IPI: Inferred from physical interaction
|
8670811 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
8670811 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in negative regulation of transcription by RNA polymerase II |
IDA
IDA: Inferred from direct assay
|
8670811 | GOA |
| involved in regulation of DNA-templated transcription |
IMP
IMP: Inferred from mutant phenotype
|
19936620 | GOA |
| involved in regulation of cell cycle |
IMP
IMP: Inferred from mutant phenotype
|
19103755 | GOA |
| involved in regulation of cell division |
IDA
IDA: Inferred from direct assay
|
20562830 | GOA |
| involved in regulation of transcription by RNA polymerase II |
IDA
IDA: Inferred from direct assay
|
22055187 | GOA |
| involved in regulation of tubulin deacetylation |
IMP
IMP: Inferred from mutant phenotype
|
20562830 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of ATAC complex |
IDA
IDA: Inferred from direct assay
|
18838386 | GOA |
| part of RNA polymerase II transcription regulator complex |
IDA
IDA: Inferred from direct assay
|
8670811 | GOA |
DR1 Protein Structure
CBFD_NFYB_HMF: Histone-like transcription factor (CBF/NF-Y) and archaeal histone (12 - 75)
- 0
- 100
- 176 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
protein Dr1 |
|
DR1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
DR1 | Q01658 | ZSCAN22 | Homo sapiens | P10073 | 32814053 | |
|
Intra
|
DR1 | Q01658 | ZSCAN22 | Homo sapiens | P10073 | 32814053 | |
|
Intra
|
DR1 | Q01658 | ZSCAN22 | Homo sapiens | P10073 | 32814053 | |
|
Intra
|
DR1 | Q01658 | TBP | Homo sapiens | Q32MN6 | 32296183 | |
|
Intra
|
DR1 | Q01658 | ASCL4 | Homo sapiens | Q6XD76 | 32814053 | |
|
Intra
|
DR1 | Q01658 | ASCL4 | Homo sapiens | Q6XD76 | 32814053 | |
|
Intra
|
DR1 | Q01658 | ASCL4 | Homo sapiens | Q6XD76 | 32814053 | |
|
Intra
|
DR1 | Q01658 | JADE3 | Homo sapiens | Q92613 | 32814053 | |
|
Intra
|
DR1 | Q01658 | JADE3 | Homo sapiens | Q92613 | 32814053 | |
|
Intra
|
DR1 | Q01658 | JADE3 | Homo sapiens | Q92613 | 32814053 | |
|
Intra
|
DR1 | Q01658 | PBX4 | Homo sapiens | Q9BYU1 | 32814053 | |
|
Intra
|
DR1 | Q01658 | PBX4 | Homo sapiens | Q9BYU1 | 32814053 | |
|
Intra
|
DR1 | Q01658 | PBX4 | Homo sapiens | Q9BYU1 | 32814053 | |
|
Intra
|
DR1 | Q01658 | q9h669_human | Homo sapiens | Q9H669 | 32814053 | |
|
Intra
|
DR1 | Q01658 | q9h669_human | Homo sapiens | Q9H669 | 32814053 | |
|
Intra
|
DR1 | Q01658 | q9h669_human | Homo sapiens | Q9H669 | 32814053 | |
|
Intra
|
DR1 | Q01658 | LARP4B | Homo sapiens | Q92615 | 32814053 | |
|
Intra
|
DR1 | Q01658 | LARP4B | Homo sapiens | Q92615 | 32814053 | |
|
Intra
|
DR1 | Q01658 | LARP4B | Homo sapiens | Q92615 | 32814053 | |
|
Intra
|
DR1 | Q01658 | MAGEC3 | Homo sapiens | Q8TD91-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | MAGEC3 | Homo sapiens | Q8TD91-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | MAGEC3 | Homo sapiens | Q8TD91-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | USP2 | Homo sapiens | O75604-3 | 32814053 | |
|
Intra
|
DR1 | Q01658 | USP2 | Homo sapiens | O75604-3 | 32814053 | |
|
Intra
|
DR1 | Q01658 | USP2 | Homo sapiens | O75604-3 | 32814053 | |
|
Intra
|
DR1 | Q01658 | C14orf93 | Homo sapiens | Q9H972-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | C14orf93 | Homo sapiens | Q9H972-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | C14orf93 | Homo sapiens | Q9H972-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | EMILIN1 | Homo sapiens | Q9Y6C2-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | EMILIN1 | Homo sapiens | Q9Y6C2-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | EMILIN1 | Homo sapiens | Q9Y6C2-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | CFAP100 | Homo sapiens | Q494V2-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | CFAP100 | Homo sapiens | Q494V2-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | CFAP100 | Homo sapiens | Q494V2-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | NFYC | Homo sapiens | Q13952-2 | 32296183 | |
|
Intra
|
DR1 | Q01658 | ZC2HC1C | Homo sapiens | Q53FD0-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | ZC2HC1C | Homo sapiens | Q53FD0-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | ZC2HC1C | Homo sapiens | Q53FD0-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | PRMT1 | Homo sapiens | Q99873-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | PRMT1 | Homo sapiens | Q99873-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | PRMT1 | Homo sapiens | Q99873-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | ZNF829 | Homo sapiens | Q3KNS6-3 | 32814053 | |
|
Intra
|
DR1 | Q01658 | ZNF829 | Homo sapiens | Q3KNS6-3 | 32814053 | |
|
Intra
|
DR1 | Q01658 | ZNF829 | Homo sapiens | Q3KNS6-3 | 32814053 | |
|
Intra
|
DR1 | Q01658 | NVL | Homo sapiens | O15381-5 | 32814053 | |
|
Intra
|
DR1 | Q01658 | NVL | Homo sapiens | O15381-5 | 32814053 | |
|
Intra
|
DR1 | Q01658 | NVL | Homo sapiens | O15381-5 | 32814053 | |
|
Intra
|
DR1 | Q01658 | DPP9 | Homo sapiens | Q86TI2-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | DPP9 | Homo sapiens | Q86TI2-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | DPP9 | Homo sapiens | Q86TI2-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | GOLGA2P5 | Homo sapiens | Q9HBQ8 | 32814053 | |
|
Intra
|
DR1 | Q01658 | GOLGA2P5 | Homo sapiens | Q9HBQ8 | 32814053 | |
|
Intra
|
DR1 | Q01658 | GOLGA2P5 | Homo sapiens | Q9HBQ8 | 32814053 | |
|
Intra
|
DR1 | Q01658 | PHF19 | Homo sapiens | Q5T6S3 | 32814053 | |
|
Intra
|
DR1 | Q01658 | PHF19 | Homo sapiens | Q5T6S3 | 32814053 | |
|
Intra
|
DR1 | Q01658 | PHF19 | Homo sapiens | Q5T6S3 | 32814053 | |
|
Intra
|
DR1 | Q01658 | RNF34 | Homo sapiens | Q969K3 | 32814053 | |
|
Intra
|
DR1 | Q01658 | RNF34 | Homo sapiens | Q969K3 | 32814053 | |
|
Intra
|
DR1 | Q01658 | RNF34 | Homo sapiens | Q969K3 | 32814053 | |
|
Intra
|
DR1 | Q01658 | DPF1 | Homo sapiens | Q92782-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | DPF1 | Homo sapiens | Q92782-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | DPF1 | Homo sapiens | Q92782-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | ANXA8 | Homo sapiens | P13928 | 32814053 | |
|
Intra
|
DR1 | Q01658 | ANXA8 | Homo sapiens | P13928 | 32814053 | |
|
Intra
|
DR1 | Q01658 | ANXA8 | Homo sapiens | P13928 | 32814053 | |
|
Intra
|
DR1 | Q01658 | ZNF488 | Homo sapiens | Q96MN9-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | ZNF488 | Homo sapiens | Q96MN9-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | ZNF488 | Homo sapiens | Q96MN9-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | HES4 | Homo sapiens | Q9HCC6 | 32814053 | |
|
Intra
|
DR1 | Q01658 | HES4 | Homo sapiens | Q9HCC6 | 32814053 | |
|
Intra
|
DR1 | Q01658 | HES4 | Homo sapiens | Q9HCC6 | 32814053 | |
|
Intra
|
DR1 | Q01658 | KLF15 | Homo sapiens | Q9UIH9 | 32814053 | |
|
Intra
|
DR1 | Q01658 | KLF15 | Homo sapiens | Q9UIH9 | 32814053 | |
|
Intra
|
DR1 | Q01658 | KLF15 | Homo sapiens | Q9UIH9 | 32814053 | |
|
Intra
|
DR1 | Q01658 | GPSM3 | Homo sapiens | Q9Y4H4 | 32814053 | |
|
Intra
|
DR1 | Q01658 | GPSM3 | Homo sapiens | Q9Y4H4 | 32814053 | |
|
Intra
|
DR1 | Q01658 | GPSM3 | Homo sapiens | Q9Y4H4 | 32814053 | |
|
Intra
|
DR1 | Q01658 | RPS4X | Homo sapiens | P62701 | 32814053 | |
|
Intra
|
DR1 | Q01658 | RPS4X | Homo sapiens | P62701 | 32814053 | |
|
Intra
|
DR1 | Q01658 | RPS4X | Homo sapiens | P62701 | 32814053 | |
|
Intra
|
DR1 | Q01658 | RPP25 | Homo sapiens | Q9BUL9 | 32814053 | |
|
Intra
|
DR1 | Q01658 | RPP25 | Homo sapiens | Q9BUL9 | 32814053 | |
|
Intra
|
DR1 | Q01658 | RPP25 | Homo sapiens | Q9BUL9 | 32814053 | |
|
Intra
|
DR1 | Q01658 | FAM117B | Homo sapiens | Q6P1L5 | 32814053 | |
|
Intra
|
DR1 | Q01658 | FAM117B | Homo sapiens | Q6P1L5 | 32814053 | |
|
Intra
|
DR1 | Q01658 | FAM117B | Homo sapiens | Q6P1L5 | 32814053 | |
|
Intra
|
DR1 | Q01658 | MYC | Homo sapiens | P01106 | 32814053 | |
|
Intra
|
DR1 | Q01658 | MYC | Homo sapiens | P01106 | 32814053 | |
|
Intra
|
DR1 | Q01658 | MYC | Homo sapiens | P01106 | 32814053 | |
|
Intra
|
DR1 | Q01658 | LPIN1 | Homo sapiens | Q14693 | 32814053 | |
|
Intra
|
DR1 | Q01658 | LPIN1 | Homo sapiens | Q14693 | 32814053 | |
|
Intra
|
DR1 | Q01658 | LPIN1 | Homo sapiens | Q14693 | 32814053 | |
|
Intra
|
DR1 | Q01658 | FAM98C | Homo sapiens | Q17RN3 | 32814053 | |
|
Intra
|
DR1 | Q01658 | FAM98C | Homo sapiens | Q17RN3 | 32814053 | |
|
Intra
|
DR1 | Q01658 | FAM98C | Homo sapiens | Q17RN3 | 32814053 | |
|
Intra
|
DR1 | Q01658 | SAP30 | Homo sapiens | O75446 | 32814053 | |
|
Intra
|
DR1 | Q01658 | SAP30 | Homo sapiens | O75446 | 32814053 | |
|
Intra
|
DR1 | Q01658 | SAP30 | Homo sapiens | O75446 | 32814053 | |
|
Intra
|
DR1 | Q01658 | VSX2 | Homo sapiens | P58304 | 32814053 | |
|
Intra
|
DR1 | Q01658 | VSX2 | Homo sapiens | P58304 | 32814053 | |
|
Intra
|
DR1 | Q01658 | VSX2 | Homo sapiens | P58304 | 32814053 | |
|
Intra
|
DR1 | Q01658 | DRAP1 | Homo sapiens | Q14919 | 31467278 | |
|
Intra
|
DR1 | Q01658 | DRAP1 | Homo sapiens | Q14919 | 29997244 | |
|
Intra
|
DR1 | Q01658 | DRAP1 | Homo sapiens | Q14919 | 18692475 | |
|
Intra
|
DR1 | Q01658 | DRAP1 | Homo sapiens | Q14919 | 29997244 | |
|
Intra
|
DR1 | Q01658 | DRAP1 | Homo sapiens | Q14919 | 31467278 | |
|
Intra
|
DR1 | Q01658 | STRN4 | Homo sapiens | Q9NRL3 | 32814053 | |
|
Intra
|
DR1 | Q01658 | STRN4 | Homo sapiens | Q9NRL3 | 32814053 | |
|
Intra
|
DR1 | Q01658 | STRN4 | Homo sapiens | Q9NRL3 | 32814053 | |
|
Intra
|
DR1 | Q01658 | MPC2 | Homo sapiens | O95563 | 32814053 | |
|
Intra
|
DR1 | Q01658 | MPC2 | Homo sapiens | O95563 | 32814053 | |
|
Intra
|
DR1 | Q01658 | MPC2 | Homo sapiens | O95563 | 32814053 | |
|
Intra
|
DR1 | Q01658 | RNF183 | Homo sapiens | Q96D59 | 32814053 | |
|
Intra
|
DR1 | Q01658 | RNF183 | Homo sapiens | Q96D59 | 32814053 | |
|
Intra
|
DR1 | Q01658 | RNF183 | Homo sapiens | Q96D59 | 32814053 | |
|
Intra
|
DR1 | Q01658 | POLE3 | Homo sapiens | Q9NRF9 | 32296183 | |
|
Intra
|
DR1 | Q01658 | POLE3 | Homo sapiens | Q9NRF9 | 16189514 | |
|
Intra
|
DR1 | Q01658 | POLE3 | Homo sapiens | Q9NRF9 | 32296183 | |
|
Intra
|
DR1 | Q01658 | ZNF581 | Homo sapiens | Q9P0T4 | 32814053 | |
|
Intra
|
DR1 | Q01658 | ZNF581 | Homo sapiens | Q9P0T4 | 32814053 | |
|
Intra
|
DR1 | Q01658 | ZNF581 | Homo sapiens | Q9P0T4 | 32814053 | |
|
Intra
|
DR1 | Q01658 | RAI2 | Homo sapiens | Q9Y5P3 | 32814053 | |
|
Intra
|
DR1 | Q01658 | RAI2 | Homo sapiens | Q9Y5P3 | 32814053 | |
|
Intra
|
DR1 | Q01658 | RAI2 | Homo sapiens | Q9Y5P3 | 32814053 | |
|
Intra
|
DR1 | Q01658 | TACO1 | Homo sapiens | Q9BSH4 | 32814053 | |
|
Intra
|
DR1 | Q01658 | TACO1 | Homo sapiens | Q9BSH4 | 32814053 | |
|
Intra
|
DR1 | Q01658 | TACO1 | Homo sapiens | Q9BSH4 | 32814053 | |
|
Intra
|
DR1 | Q01658 | GMPPA | Homo sapiens | Q96IJ6 | 32814053 | |
|
Intra
|
DR1 | Q01658 | GMPPA | Homo sapiens | Q96IJ6 | 32814053 | |
|
Intra
|
DR1 | Q01658 | GMPPA | Homo sapiens | Q96IJ6 | 32814053 | |
|
Intra
|
DR1 | Q01658 | SEM1 | Homo sapiens | P60896 | 32814053 | |
|
Intra
|
DR1 | Q01658 | SEM1 | Homo sapiens | P60896 | 32814053 | |
|
Intra
|
DR1 | Q01658 | SEM1 | Homo sapiens | P60896 | 32814053 | |
|
Intra
|
DR1 | Q01658 | SPPL2B | Homo sapiens | Q8TCT7-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | SPPL2B | Homo sapiens | Q8TCT7-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | SPPL2B | Homo sapiens | Q8TCT7-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | FAM9A | Homo sapiens | Q8IZU1 | 32814053 | |
|
Intra
|
DR1 | Q01658 | FAM9A | Homo sapiens | Q8IZU1 | 32814053 | |
|
Intra
|
DR1 | Q01658 | FAM9A | Homo sapiens | Q8IZU1 | 32814053 | |
|
Intra
|
DR1 | Q01658 | TIMM44 | Homo sapiens | O43615 | 32814053 | |
|
Intra
|
DR1 | Q01658 | TIMM44 | Homo sapiens | O43615 | 32814053 | |
|
Intra
|
DR1 | Q01658 | TIMM44 | Homo sapiens | O43615 | 32814053 | |
|
Intra
|
DR1 | Q01658 | CSNK1D | Homo sapiens | P48730-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | CSNK1D | Homo sapiens | P48730-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | CSNK1D | Homo sapiens | P48730-2 | 32814053 | |
|
Intra
|
DR1 | Q01658 | LOC401296 | Homo sapiens | A2RU56 | 32814053 | |
|
Intra
|
DR1 | Q01658 | LOC401296 | Homo sapiens | A2RU56 | 32814053 | |
|
Intra
|
DR1 | Q01658 | LOC401296 | Homo sapiens | A2RU56 | 32814053 |
DR1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P89757 | DR1 Antibody (YA9101) | WB, ICC/IF, IF-Tissue, IP, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Oesophagostomiasis |
|
|
| Trichostrongylosis |
|
|
| Recessive Dystrophic Epidermolysis Bullosa |
|
|
| Epidermolysis Bullosa Dystrophica, Pretibial |
|
|
| Corneal Dystrophy, Subepithelial Mucinous |
|
|
| Spondyloepimetaphyseal Dysplasia, Strudwick Type |
|
|
| Trichostrongyloidiasis |
|
|
| Anisakiasis |
|
|
| Metaphyseal Chondrodysplasia, Schmid Type |
|
|
| Ancylostomiasis |
|
|
| Transient Bullous Dermolysis Of The Newborn |
|
|
| Traumatic Glaucoma |
|
|
| Epidermolysis Bullosa Dystrophica |
|
|
| Internal Hordeolum |
|
|
| Noonan Syndrome 2 |
|
|
| Hypoparathyroidism-Deafness-Renal Disease Syndrome |
|
|
| Acquired Color Blindness |
|
|
| Toxocariasis |
|
|
| Bullous Skin Disease |
|
|
| Epithelial And Subepithelial Dystrophy |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | DR1 | VGNC | VGNC:80190 |
| Mus musculus | DR1 | MGD | MGI:1100515 |
| Bos taurus | DR1 | VGNC | VGNC:28200 |
| Rattus norvegicus | DR1 | RGD | RGD:1305201 |
| Canis familiaris | DR1 | VGNC | VGNC:40087 |
| Others | DR1 | NCBI |