1. Apoptosis
  2. Bcl-2 Family
    Apoptosis
  3. UBX1325

UBX1325 

Cat. No.: HY-150069
Handling Instructions

UBX1325 is an Bcl-xL inhibitor that promotes apoptosis in senescent cells. UBX1325 is a potent anti-aging agent that can be used in studies of age-related eye diseases such as diabetic macular oedema (DME), age-related macular degeneration (AMD) and diabetic retinopathy (DR).

For research use only. We do not sell to patients.

UBX1325 Chemical Structure

UBX1325 Chemical Structure

CAS No. : 2271269-01-1

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Description

UBX1325 is an Bcl-xL inhibitor that promotes apoptosis in senescent cells. UBX1325 is a potent anti-aging agent that can be used in studies of age-related eye diseases such as diabetic macular oedema (DME), age-related macular degeneration (AMD) and diabetic retinopathy (DR)[1].

In Vitro

UBX1325 leads to a decrease in the anti-apoptotic Bcl-xL:Bim complex in retina by intravitreal (IVT) injection administration in oxygen induced retinopathy (OIR) C57BL/6 mice model[1].
UBX1325 can cause a decrease in retinal vascular permeability and promote retinal neovascularization in streptozotocin (STZ)-induced retinopathy mice model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1159.69

Formula

C53H59ClF3N6O10PS3

CAS No.
SMILES

CC1=C(C(C2=CC=CC(N3CCN(CC3)C4=CC=C(C=C4)NS(=O)(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[[email protected]@H](CSC6=CC=CC=C6)CCN7CCC(CC7)OP(O)(O)=O)=O)=C2)=C(N1C(C)C)C8=CC=C(C=C8)Cl)C(O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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UBX1325
Cat. No.:
HY-150069
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