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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
25 Results for "
55592
" in MedChemExpress (MCE) Product Catalog:
Products (25)
25 Results for "55592" in MCE Product Catalog:
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6 Cited Publications
RMC-5552 is a potent and selective mTORC1 inhibitor. RMC-5552 inhibits phosphorylation of mTORC1 pS6K and p4EBP1 with IC50s of 0.14 nM and 0.48 nM, respectively. RMC-5552 shows much lower pAKT inhibition (IC50 of 19 nM), resulting in mTORC1/mTORC2 selectivity approaching 40-fold. RMC-5552 has anti-cancer activity .
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Dorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes .
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Nisoldipine (BAY-k 5552; Sular) is an orally active and blood-brain barrier-penetrating dihydropyridine calcium antagonist, with greater vascular selectivity than other calcium channel antagonists. Nisoldipine inhibits calcium influx and blocks voltage-gated calcium channels. Nisoldipine dilates coronary and systemic arteries. Nisoldipine has antihypertensive and anti-anginal activity. Nisoldipine also displays neuroprotective and antiviral activity .
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1 Cited Publications
Cat. No.: HY-P99381
CAS No.: 1221901-33-2
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(32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. (32-Carbonyl)-RMC-5552 inhibits mTORC1 and mTORC2 substrate (p-P70S6K-(T389), p-4E-BP1-(T37/36), AND p-AKT1/2/3-(S473)) phosphorylation with pIC50s of > 9, >9 and between 8 and 9, respectively (patent WO2019212990A1, example 2) .
Cat. No.: HY-W010869
CAS No.: 172854-55-6
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GR 55562 hydrochloride is a selective 5-HT1B receptor antagonist. GR 55562 hydrochloride can be used for the research of nerve disease .
Cat. No.: HY-17373R
CAS No.: 171228-49-2
Synonyms: SCH 56592 (Standard)
Target:
Posaconazole (Standard) is the analytical standard of Posaconazole. This product is intended for research and analytical applications. Posaconazole is a broad-spectrum, second generation, triazole compound with antifungal activity.
Cat. No.: HY-109030R
CAS No.: 1191995-00-2
Synonyms: HMS5552 (Standard)
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Dorzagliatin (Standard) is the analytical standard of Dorzagliatin. This product is intended for research and analytical applications. Dorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes .
Cat. No.: HY-17373S
CAS No.: 1217785-83-5
Synonyms: SCH 56592-d5
Cat. No.: HY-101367
CAS No.: 159533-26-3
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GR 55562 is a selective 5-HT1B receptor antagonist. GR 55562 can be used for the research of nerve disease .
Cat. No.: HY-172565
Synonyms: SCH 56592 D-glucuronide
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Research Areas:
Posaconazole D-glucuronide (SCH 56592 D-glucuronide) is a glucuronide metabolite of the antifungal agent Posaconazole (HY-17373). Posaconazole D-glucuronide can be formed in human liver microsomes catalyzed by UGT1A4 .
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GR 55562 dihydrochloride is a selective 5-HT1B receptor antagonist. GR 55562 dihydrochloride can be used for the research of nerve disease .
Cat. No.: HY-17402R
CAS No.: 63675-72-9
Synonyms: BAY-k 5552 (Standard)
Research Areas:
Nisoldipine (Standard) is the analytical standard of Nisoldipine. This product is intended for research and analytical applications. Nisoldipine (BAY-k 5552; Sular) is a highly efficient and specific L-type Cav1.2 channel blocker with an IC50 of 10 nM.
Cat. No.: HY-124874
CAS No.: 195966-93-9
Synonyms: (rel)-Aspergillimide; (rel)-VM55598
Category:
Target:
Cat. No.: HY-17373S2
Synonyms: SCH 56592-d3
Cat. No.: HY-17373S3
Synonyms: SCH 56592-d7
Cat. No.: HY-17402S
CAS No.: 1285910-03-3
Synonyms: BAY-k 5552-d6
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
