MPC2 - mitochondrial pyruvate carrier 2 Gene

Also Known as BRP44; SLC54A2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25874

About MPC2

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:167,916,675-167,937,072 (from NCBI)

This gene has 3 transcripts (splice variants), 257 orthologues and 2 paralogues. Broad expression in kidney (RPKM 34.8), liver (RPKM 32.8) and 25 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in mitochondrial pyruvate transmembrane transport. Predicted to act upstream of or within mitochondrial acetyl-CoA biosynthetic process from pyruvate and positive regulation of Insulin secretion involved in cellular response to glucose stimulus. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

MPC2 Products (2)

mRNA Protein Name
NM_001143674.4 NP_001137146.1 mitochondrial pyruvate carrier 2
NM_015415.3 NP_056230.1 mitochondrial pyruvate carrier 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
31145700 GOA
Biological Process GO Annotation Evidence References Source
involved in mitochondrial pyruvate transmembrane transport IDA
IDA: Inferred from direct assay
26253029 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
26253029 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MPC2 Protein Structure

MPC

MPC: Uncharacterised protein family (UPF0041) (27 - 126)

  • 0
  • 100
  • 127 a.a.
Protein Preferred Names Protein Names

mitochondrial pyruvate carrier 2

  • brain protein 44

MPC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MPC2 O95563 SYT16 Homo sapiens Q17RD7
Validated Y2H
32296183
Intra
MPC2 O95563 TEX44 Homo sapiens Q53QW1
Validated Y2H
32296183
Intra
MPC2 O95563 APOC1 Homo sapiens P02654
Y2H Array
32296183
Intra
MPC2 O95563 APOC1 Homo sapiens P02654
Validated Y2H
32296183
Intra
MPC2 O95563 APOC1 Homo sapiens P02654
Y2H Prey Pooling
32296183
Intra
MPC2 O95563 MICOS10 Homo sapiens Q5TGZ0
Validated Y2H
32296183
Intra
MPC2 O95563 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Array
32296183
Intra
MPC2 O95563 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Prey Pooling
32296183
Intra
MPC2 O95563 RHBDD2 Homo sapiens Q6NTF9-3
Validated Y2H
32296183
Intra
MPC2 O95563 SNX1 Homo sapiens Q13596
Validated Y2H
32296183
Intra
MPC2 O95563 MPC1L Homo sapiens P0DKB6
TSA
35278701
Intra
MPC2 O95563 MPC1L Homo sapiens P0DKB6
Light Scattering
35278701
Intra
MPC2 O95563 MPC1L Homo sapiens P0DKB6
Pull Down
35278701
Intra
MPC2 O95563 MPC1L Homo sapiens P0DKB6
GMS
35278701
Intra
MPC2 O95563 DIABLO Homo sapiens Q9NR28
Validated Y2H
32296183
Intra
MPC2 O95563 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
Intra
MPC2 O95563 CIDEB Homo sapiens Q9UHD4
Validated Y2H
32296183
Intra
MPC2 O95563 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
Intra
MPC2 O95563 MPC1 Homo sapiens Q9Y5U8
Pull Down
35278701
Intra
MPC2 O95563 MPC1 Homo sapiens Q9Y5U8
Validated Y2H
32296183
Intra
MPC2 O95563 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mitochondrial Pyruvate Carrier Deficiency

  • MPYCD
Colon Mucinous Adenocarcinoma

  • Colonic Mucinous Adenocarcinoma

  • Mucinous Adenocarcinoma Of The Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08607 MPC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19353 Mpc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20702 Cbx4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25844 Mpc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MPC2 VGNC VGNC:107897
Mus musculus MPC2 MGD MGI:1917706
Bos taurus MPC2 VGNC VGNC:31570
Macaca mulatta MPC2 VGNC VGNC:97793
Canis familiaris MPC2 VGNC VGNC:43330
Rattus norvegicus MPC2 RGD RGD:1563422
Others MPC2 NCBI