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Cat. No.: HY-136393

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IKK-IN-4

IKK-IN-4 is a potent and selective IkappaB kinase 2 (IKKβ orIKK2) inhibitor, with IC₅₀s of 45 and 650 nM for IKKβ and IKKα, respectively.

For research use only. We do not sell to patients.

CAS No.: 615529-94-7
Formula: C₁₈H₁₉N₅S
Molecular Weight:337.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

IKK-IN-4 Chemical Structure

CAS No.: 615529-94-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IKK-IN-4 is a potent and selective IkappaB kinase 2 (IKKβ orIKK2) inhibitor, with IC₅₀s of 45 and 650 nM for IKKβ and IKKα, respectively^[1].

All IKK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Jurkat	CC₅₀	21 μM Compound: 22f	Cytotoxicity against Jurkat cells by Alamar blue assay Cytotoxicity against Jurkat cells by Alamar blue assay	[PMID: 17540562]
Jurkat	EC₅₀	6.73 μM Compound: 22f	Inhibition of LPS-induced TNFalpha production in Jurkat cells Inhibition of LPS-induced TNFalpha production in Jurkat cells	[PMID: 17540562]

Chemical Information

CAS No. 615529-94-7
Molecular Weight 337.44
Formula C₁₈H₁₉N₅S
SMILES

CC1=CN=C2C(NC)=NC(C=C(C3=CC=CC(CCN)=C3)S4)=C4N21
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Belema M, et al. Synthesis and structure-activity relationship of imidazo(1,2-a)thieno(3,2-e)pyrazines as IKK-beta inhibitors. Bioorg Med Chem Lett. 2007;17(15):4284‐4289. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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IKK-IN-4

All IKK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

IKK-IN-4 Related Classifications

HY-136393 Related Classifications