4-Methoxybiphenyl
Based on 1 Customer Validation
4-Methoxybiphenyl is a cytochrome P450-dependent microsomal monooxygenase system substrate and metabolite precursor. 4-Methoxybiphenyl undergoes O-demethylation to generate 4-hydroxybiphenyl. 4-Methoxybiphenyl undergoes sulphation and glucuronidation conjugation; inhibition of sulphation shifts metabolism toward increased glucuronidation and unconjugated 4-hydroxybiphenyl accumulation. 4-Methoxybiphenyl serves as a model substrate for studying phase II metabolic conjugation pathway balance in rat isolated hepatocytes.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 613-37-6
- 分子式: C13H12O
- 分子量:184.24
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保管条件:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
17 μg/mL
Compound: 19
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Cytotoxicity against HEK293 cells assessed as reduction in cell growth after 3 days by MTT assay
Cytotoxicity against HEK293 cells assessed as reduction in cell growth after 3 days by MTT assay
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[PMID: 27259399] |
| HT-29 | IC50 |
45 μg/mL
Compound: 19
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Cytotoxicity against human HT-29 cells assessed as reduction in cell growth after 3 days by MTT assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell growth after 3 days by MTT assay
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[PMID: 27259399] |
| MCF7 | IC50 |
>100 μg/mL
Compound: 19
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Cytotoxicity against human MCF7 cells assessed as reduction in cell growth after 3 days by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell growth after 3 days by MTT assay
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[PMID: 27259399] |
4-Methoxybiphenyl (100 μM; 20 min) metabolism by isolated male Wistar rat hepatocytes produces 4-OHBP via O-demethylation, which is conjugated into sulphate and glucuronide conjugates; inhibition of sulphation (via 50 μM DCNP or sulphate-free medium) significantly increases 4-OHBP glucuronide, unconjugated 4-OHBP, and total 4-OHBP levels, with total 4-OHBP reaching 19.47 nmol/2 × 106 cells/20 min with 50 μM DCNP and 20.01 nmol/2 × 106 cells/20 min in sulphate-free medium[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 613-37-6
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性状 Solid
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分子量 184.24
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分子式 C13H12O
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SMILES
COC1=CC=C(C=C1)C2=CC=CC=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
純度とドキュメンテーション
参考文献
[1]. Fry JR, et al. Influence of the sulphation inhibitor, 2,6-dichloro-4-nitrophenol, on the production and conjugation, of 4-hydroxybiphenyl generated from 4-methoxybiphenyl by rat isolated hepatocytes. Biochem Pharmacol. 1987 Sep 15;36(18):3090-2. doi: 10.1016/0006-2952(87)90232-2. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
4-Methoxybiphenyl 関連分類
HY-129565 関連分類
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