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製品番号: HY-124199

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Cephalochromin

Cephalochromin is an antibiotic and an inhibitor for bacterial fatty acid synthase (FabI). Cephalochromin inhibits FabI of Staphylococcus aureus and Escherichia coli with IC₅₀ of 1.9 and 1.8 μM. Cephalochromin inhibits gram-positive methicillin-resistant S. aureus (MRSA) and quinolone-resistant S. aureus (QRSA), with MIC of 2-8 µg/mL.

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CAS 番号: 25908-26-3
分子式: C₂₈H₂₂O₁₀
分子量:518.47

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

Cephalochromin 構造式

CAS 番号: 25908-26-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

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Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	2.72 μM Compound: Cephalochromin	Cytotoxicity against human A549 cells after 48 hrs by SRB assay Cytotoxicity against human A549 cells after 48 hrs by SRB assay	[PMID: 24588135]
A549	IC₅₀	5.22 μM Compound: Cephalochromin	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 24588135]
BHK-21	IC₅₀	20 μM Compound: Cephalochromin	Antagonist activity at human glucagon receptor expressed in BHK21 cells assessed as inhibition of glucagon-induced cAMP elevation by RIA Antagonist activity at human glucagon receptor expressed in BHK21 cells assessed as inhibition of glucagon-induced cAMP elevation by RIA	[PMID: 15387654]
Caco-2	IC₅₀	12.4 μM Compound: Cephalochromin	Cytotoxicity against human Caco2 cells after 48 hrs by MTT assay Cytotoxicity against human Caco2 cells after 48 hrs by MTT assay	[PMID: 24588135]
Hep 3B2	IC₅₀	14.31 μM Compound: Cephalochromin	Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay Cytotoxicity against human Hep3B cells after 48 hrs by MTT assay	[PMID: 24588135]
HT-1080	IC₅₀	4.98 μM Compound: Cephalochromin	Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay	[PMID: 24588135]
Huh-7	IC₅₀	4.64 μM Compound: Cephalochromin	Cytotoxicity against human HuH7 cells after 48 hrs by MTT assay Cytotoxicity against human HuH7 cells after 48 hrs by MTT assay	[PMID: 24588135]
SW1353	IC₅₀	3.54 μM Compound: Cephalochromin	Cytotoxicity against human SW1353 cells after 48 hrs by MTT assay Cytotoxicity against human SW1353 cells after 48 hrs by MTT assay	[PMID: 24588135]

化学情報

CAS 番号 25908-26-3
分子量 518.47
分子式 C₂₈H₂₂O₁₀
SMILES

OC(C(C(C=C1O[C@@H](C2)C)=[C@@](C(O)=C3)[C@@](C(O)=C4)=C(C=C5O[C@@H](C6)C)C(C(O)=C5C6=O)=C4O)=C3O)=C1C2=O
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
Cephalosporium caerulens
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (278 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Zheng CJ, et al., Cephalochromin, a FabI-directed antibacterial of microbial origin. Biochem Biophys Res Commun. 2007 Nov 3;362(4):1107-12. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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参考文献

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Cephalochromin

Antibiotic アイソフォーム固有の製品をすべて表示