COX-2-IN-51
COX-2-IN-51 (E25) is a potent COX-2 inhibitor, with an IC50 of 70.7 nM. COX-2-IN-51 significantly inhibits LPS-induced release of NO and PGE2, expression of COX-2 and iNOS, and activation of NF-κB pathway. COX-2-IN-51 exhibits anti-inflammatory and analgesic effects in diverse murine models through inhibiting NF-κB pathway. COX-2-IN-51 has lower gastrointestinal side effects than Indomethacin (HY-14397).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3064260-49-4
- 分子式: C23H18F4O3S
- 分子量:450.45
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
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COX-2 70.7 nM (IC50) |
化学情報
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CAS 番号 3064260-49-4
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分子量 450.45
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分子式 C23H18F4O3S
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SMILES
FC1=CC=C(OC(OCCC2=CSC=C2)(C(F)(F)F)C(C3=CC=C(OC)C=C3)=C4)C4=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)