DTX-P7
DTX-P7 is a peptide-drug conjugate. DTX-P7, composed of Docetaxel (DTX, HY-B0011) and a heptapeptide (P7), induces unfolded protein response and subsequent apoptosis by degrading Hsp90.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C84H118N8O25
- 分子量:1639.87
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
11.4 nM
|
|
PMID: 35659720 |
| C3H/3T3 | IC50 |
11.4 nM
|
|
PMID: 35659720 |
| H1975 | IC50 |
0.62 nM
|
|
PMID: 35659720 |
| M21 | IC50 |
0.62 nM
|
|
PMID: 35659720 |
DTX-P7 inhibits the expression of membrane Hsp90 in dose- and time-dependent manners, while no change in mRNA level is observed[1].
DTX-P7 enhances phosphorylation of PERK and eIF2α, whereas no XBP-1 RNA splicing is observed when A549 cells are exposed[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 1639.87
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分子式 C84H118N8O25
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
DTX-P7 関連分類
HY-P10757 関連分類
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